Aaron Donald and Kevin Greene are tied for the most career sacks against the 49ers, with 12.5 sacks.
Interpreted as:
most defensive sacks by a player against 49ers all-time| NAME | SCK | GP | TKL | AST | COMB | SCKY | INT | INT YDS | INT TD | FF | FR | FR TD | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | A. Donald | 12.5 | 18 | 55 | 22 | 77 | 84 | 0 | 0 | 0 | 3 | 1 | 0 |
| 2 |  | K. Greene | 12.5 | 21 | 0 | 0 | 0 | 0 | ||||||
| 3 |  | R. Jackson | 10.5 | 23 | 2 | 32 | 0 | 0 | ||||||
| 4 | | L. Little | 10.0 | 16 | 40 | 11 | 51 | 0 | 0 | 0 | 5 | 0 | ||
| 5 | | M. Bennett | 9.5 | 12 | 26 | 7 | 33 | 53 | 0 | 0 | 0 | 0 | 0 | 0 |
| 6 | | R. Turnbull | 9.5 | 16 | 0 | 0 | 0 | 0 | ||||||
| 7 | | J. Hall | 9.0 | 12 | 40 | 4 | 44 | 58 | 0 | 0 | 0 | 3 | 1 | 0 |
| 8 | | C. Smith | 9.0 | 16 | 2 | 57 | 1 | 0 | ||||||
| 9 | | P. Swilling | 9.0 | 16 | 0 | 0 | 0 | 0 | ||||||
| 10 | | B. Berry | 8.5 | 11 | 14 | 2 | 16 | 0 | 0 | 0 | 4 | 0 | ||
| 11 | | H. Thomas | 8.5 | 8 | 0 | 0 | 0 | 0 | ||||||
| 12 |  | C. Jones | 8.0 | 12 | 27 | 6 | 33 | 43 | 0 | 0 | 0 | 1 | 1 | 0 |
| 13 | | C. Campbell | 8.0 | 21 | 58 | 14 | 72 | 39 | 1 | 1 | 0 | 0 | 0 | 0 |
| 14 | | W. Martin | 8.0 | 21 | 0 | 0 | 0 | 0 | ||||||
| 15 |  | R. White | 8.0 | 8 | 0 | 0 | 0 | 0 | ||||||
| 16 | | J. Wilks | 7.5 | 20 | 0 | 0 | 0 | 0 | ||||||
| 17 |  | D. Ware | 7.0 | 4 | 12 | 0 | 12 | 47 | 0 | 0 | 0 | 0 | 0 | 0 |
| 18 | | D. Dockett | 7.0 | 20 | 42 | 8 | 50 | 59 | 1 | 3 | 0 | 2 | 2 | 0 |
| 19 | | R. Bernard | 7.0 | 14 | 24 | 12 | 36 | 51 | 0 | 0 | 0 | 1 | 1 | 0 |
| 20 | | P. Kerney | 7.0 | 13 | 23 | 6 | 29 | 0 | 0 | 0 | 2 | 0 | ||
| 21 | | R. Dent | 7.0 | 7 | 0 | 0 | 0 | 0 | ||||||
| 22 | | J. Reed | 6.5 | 16 | 17 | 29 | 46 | 55.5 | 0 | 0 | 0 | 1 | 0 | 0 |
| 23 | | M. Golden | 6.5 | 13 | 31 | 12 | 43 | 38 | 0 | 0 | 0 | 0 | 0 | 0 |
| 24 | | C. Long | 6.5 | 15 | 26 | 5 | 31 | 44 | 0 | 0 | 0 | 1 | 0 | 0 |
| 25 | | M. Brockers | 6.0 | 19 | 40 | 23 | 63 | 32 | 0 | 0 | 0 | 0 | 0 | 0 |
StatMuse has game-level data for sacks going back to the 1982 season.
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| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |