The Cleveland Browns and the Los Angeles Chargers were tied for the highest total-points differential in a game in 2021, with a +42 differential on October 10.

which teams had the best o/u differential last season, by game
10/10/2021Browns10/10/2021Chargers1/2/2022Lions1/2/2022Seahawks12/12/2021Bears12/12/2021Packers1/8/2022Eagles1/8/2022Cowboys11/21/2021Steelers11/21/2021Chargers11/4/2021Colts11/4/2021Jets9/12/2021Lions9/12/202149ers11/21/2021Eagles11/21/2021Saints12/26/2021Chargers12/26/2021Texans10/24/2021Patriots10/24/2021Jets1/23/2022Bills1/23/2022Chiefs+42+42+38.5+38.5+32+32+31+31+30.5+30.5+29.5+29.5+29+29+27+27+24.5+24.5+24.5+24.5+24+24
TEAMDATETMOPPRESULTSPREADATS DIFFO/UO/U DIFFTD1DWNOFFOPP OFF3DWN%4DWN%
Cleveland BrownsCleveland Browns10/10/2021
CLECLE
+115@
LACLAC
-137
L
42-47
+2.5-2.5 (N)47+42 (O)52553149333.333.3
Los Angeles ChargersLos Angeles Chargers10/10/2021
LACLAC
-137vs
CLECLE
+115
W
47-42
-2.5+2.5 (Y)47+42 (O)72749353146.2100.0
Detroit LionsDetroit Lions1/2/2022
DETDET
+321@
SEASEA
-414
L
29-51
+8.5-13.5 (N)41.5+38.5 (O)42035749750.050.0
Seattle SeahawksSeattle Seahawks1/2/2022
SEASEA
-414vs
DETDET
+321
W
51-29
-8.5+13.5 (Y)41.5+38.5 (O)62949735758.3100.0
Chicago BearsChicago Bears12/12/2021
CHICHI
+468@
GBGB
-679
L
30-45
+11.5-3.5 (N)43+32 (O)31634743938.50.0
Green Bay PackersGreen Bay Packers12/12/2021
GBGB
-679vs
CHICHI
+468
W
45-30
-11.5+3.5 (Y)43+32 (O)62743934740.0100.0
Philadelphia EaglesPhiladelphia Eagles1/8/2022
PHIPHI
+216vs
DALDAL
-268
L
26-51
+6-19 (N)46+31 (O)32231547555.6100.0
Dallas CowboysDallas Cowboys1/8/2022
DALDAL
-268@
PHIPHI
+216
W
51-26
-6+19 (Y)46+31 (O)72247531561.5100.0
Pittsburgh SteelersPittsburgh Steelers11/21/2021
PITPIT
+223@
LACLAC
-277
L
37-41
+6.5+2.5 (Y)47.5+30.5 (O)42230053353.30.0
Los Angeles ChargersLos Angeles Chargers11/21/2021
LACLAC
-277vs
PITPIT
+223
W
41-37
-6.5-2.5 (N)47.5+30.5 (O)53353330058.30.0
Indianapolis ColtsIndianapolis Colts11/4/2021
INDIND
-508vs
NYJNYJ
+379
W
45-30
-10+5 (Y)45.5+29.5 (O)62853248650.050.0
New York JetsNew York Jets11/4/2021
NYJNYJ
+379@
INDIND
-508
L
30-45
+10-5 (N)45.5+29.5 (O)43048653257.1100.0
Detroit LionsDetroit Lions9/12/2021
DETDET
+285vs
SFSF
-371
L
33-41
+7.5-0.5 (N)45+29 (O)43143044226.740.0
San Francisco 49ersSan Francisco 49ers9/12/2021
SFSF
-371@
DETDET
+285
W
41-33
-7.5+0.5 (Y)45+29 (O)52144243033.3
Philadelphia EaglesPhiladelphia Eagles11/21/2021
PHIPHI
-154vs
NONO
+130
W
40-29
-3+8 (Y)42+27 (O)42138032357.1
New Orleans SaintsNew Orleans Saints11/21/2021
NONO
+130@
PHIPHI
-154
L
29-40
+3-8 (N)42+27 (O)41832338046.2
Los Angeles ChargersLos Angeles Chargers12/26/2021
LACLAC
-670@
HOUHOU
+470
L
29-41
-13-25 (N)45.5+24.5 (O)32541743766.7
Houston TexansHouston Texans12/26/2021
HOUHOU
+470vs
LACLAC
-670
W
41-29
+13+25 (Y)45.5+24.5 (O)52643741769.2
New England PatriotsNew England Patriots10/24/2021
NENE
-334vs
NYJNYJ
+262
W
54-13
-7+34 (Y)42.5+24.5 (O)73255129958.3100.0
New York JetsNew York Jets10/24/2021
NYJNYJ
+262@
NENE
-334
L
13-54
+7-34 (N)42.5+24.5 (O)21829955153.80.0
Buffalo BillsBuffalo Bills1/23/2022
BUFBUF
+112@
KCKC
-133
L
36-42
+2.5-3.5 (N)54+24 (O)52342255242.9100.0
Kansas City ChiefsKansas City Chiefs1/23/2022
KCKC
-133vs
BUFBUF
+112
W
42-36
-2.5+3.5 (Y)54+24 (O)53055242261.5100.0
Washington Football TeamWashington Football Team12/26/2021
WASWAS
+366@
DALDAL
-486
L
14-56
+10-32 (N)46+24 (O)21425749723.150.0
Dallas CowboysDallas Cowboys12/26/2021
DALDAL
-486vs
WASWAS
+366
W
56-14
-10+32 (Y)46+24 (O)82849725766.7100.0
Green Bay PackersGreen Bay Packers1/9/2022
GBGB
-201@
DETDET
+166
L
30-37
-4-11 (N)45+22 (O)42237840457.150.0
Detroit LionsDetroit Lions1/9/2022
DETDET
+166vs
GBGB
-201
W
37-30
+4+11 (Y)45+22 (O)41940437836.466.7
New York JetsNew York Jets10/31/2021
NYJNYJ
+420vs
CINCIN
-580
W
34-31
+11.5+14.5 (Y)43+22 (O)43251131854.5
Cincinnati BengalsCincinnati Bengals10/31/2021
CINCIN
-580@
NYJNYJ
+420
L
31-34
-11.5-14.5 (N)43+22 (O)41831851140.00.0
Buffalo BillsBuffalo Bills1/15/2022
BUFBUF
-216vs
NENE
+175
W
47-17
-4.5+25.5 (Y)43+21 (O)72948230585.7
New England PatriotsNew England Patriots1/15/2022
NENE
+175@
BUFBUF
-216
L
17-47
+4.5-25.5 (N)43+21 (O)22030548250.0100.0
Atlanta FalconsAtlanta Falcons9/19/2021
ATLATL
+540@
TBTB
-771
L
25-48
+12.5-10.5 (N)52+21 (O)31934834140.025.0
Tampa Bay BuccaneersTampa Bay Buccaneers9/19/2021
TBTB
-771vs
ATLATL
+540
W
48-25
-12.5+10.5 (Y)52+21 (O)72134134833.350.0