The Vegas Golden Knights had the highest goal differential by a team in 2020-21, with a differential of 68 goals.

TEAM	DIFF	SEASON	GP	W	L	OTL	PTS	PTS%	G	GA	PP%	PK%	S/GP	SA/GP
Vegas Golden Knights	68	2020-21	56	40	14	2	82	.732	190	122	17.8	86.8	32.66	27.27
Colorado Avalanche	65	2020-21	56	39	13	4	82	.732	197	132	22.7	83.1	34.59	25.41
Carolina Hurricanes	41	2020-21	56	36	12	8	80	.714	175	134	25.6	85.2	32.04	28.25
Toronto Maple Leafs	38	2020-21	56	35	14	7	77	.688	186	148	20.0	78.5	31.27	27.82
Pittsburgh Penguins	38	2020-21	56	37	16	3	77	.688	193	155	23.7	77.4	30.07	29.98
Florida Panthers	37	2020-21	56	37	14	5	79	.705	188	151	20.5	79.8	34.91	30.04
Tampa Bay Lightning	35	2020-21	56	36	17	3	75	.670	180	145	22.2	84.2	30.21	28.27
Boston Bruins	30	2020-21	56	33	16	7	73	.652	164	134	21.9	86.0	33.32	27.07
Edmonton Oilers	29	2020-21	56	35	19	2	72	.643	183	154	27.6	82.5	29.89	30.66
New York Islanders	27	2020-21	56	32	17	7	71	.634	152	125	18.8	83.7	28.98	28.39
Washington Capitals	27	2020-21	56	36	15	5	77	.688	188	161	24.8	84.0	29.41	28.79
New York Rangers	21	2020-21	56	27	23	6	60	.536	176	155	20.7	82.2	28.70	29.71
Minnesota Wild	21	2020-21	56	35	16	5	75	.670	180	159	17.6	80.7	28.30	30.45
Winnipeg Jets	18	2020-21	56	30	23	3	63	.563	170	152	23.0	80.5	29.66	30.59
Dallas Stars	8	2020-21	56	23	19	14	60	.536	156	148	23.6	79.1	30.34	27.11
St. Louis Blues	0	2020-21	56	27	20	9	63	.563	167	167	23.2	77.8	28.96	29.82
Nashville Predators	-3	2020-21	56	31	23	2	64	.571	151	154	17.6	75.6	29.98	31.30
Calgary Flames	-5	2020-21	56	26	27	3	55	.491	155	160	18.3	80.2	30.16	28.16
Montreal Canadiens	-7	2020-21	56	24	21	11	59	.527	158	165	19.2	78.5	31.18	28.20
Arizona Coyotes	-24	2020-21	56	24	26	6	54	.482	150	174	20.8	80.8	27.46	30.46
Chicago Blackhawks	-25	2020-21	56	24	25	7	55	.491	159	184	21.7	76.8	29.20	33.71
Los Angeles Kings	-27	2020-21	56	21	28	7	49	.438	142	169	18.9	83.6	28.34	31.18
Ottawa Senators	-34	2020-21	56	23	28	5	51	.455	155	189	15.5	78.9	29.70	32.13
Philadelphia Flyers	-37	2020-21	56	25	23	8	58	.518	160	197	19.2	73.1	30.21	29.21
Vancouver Canucks	-39	2020-21	56	23	29	4	50	.446	148	187	17.4	79.8	29.09	33.39