Between the 1999-00 and 2008-09 seasons, Martin Brodeur had the most wins by a goalie, with 356 wins.

Interpreted as:

most regular-season wins by goaltender in 2000s NHL

	NAME	W	GP	GS	L	T	OTL	SA	SV	SV%	GA	GAA	SHO	MIN
1	Martin Brodeur M. Brodeur	356	624	623	194	48	23	16,011	14,628	.914	1,383	2.22	65	37394
2	Evgeni Nabokov E. Nabokov	249	492	482	162	29	27	12,589	11,465	.911	1,124	2.38	47	28297
3	Marty Turco M. Turco	240	456	433	134	26	26	10,933	9,955	.911	978	2.26	36	25976
4	Olie Kolzig O. Kolzig	230	520	513	212	42	24	15,184	13,773	.907	1,411	2.76	24	30667
5	Roberto Luongo R. Luongo	230	544	526	232	33	31	16,430	15,101	.919	1,329	2.57	47	31038
6	Chris Osgood C. Osgood	223	426	407	127	32	23	10,651	9,622	.903	1,029	2.55	26	24189
7	Ed Belfour E. Belfour	208	413	404	146	36	14	10,862	9,864	.908	998	2.48	31	24144
8	Curtis Joseph C. Joseph	206	419	397	156	29	6	11,126	10,083	.906	1,043	2.62	29	23898
9	Jose Theodore J. Theodore	206	466	445	196	28	15	12,859	11,697	.910	1,162	2.61	27	26669
10	Tomas Vokoun T. Vokoun	205	474	454	193	31	25	13,606	12,462	.916	1,144	2.52	30	27189
11	Miikka Kiprusoff M. Kiprusoff	204	385	371	125	7	35	10,454	9,538	.912	916	2.46	30	22306
12	Jean-Sebastien Giguere J. Giguere	203	434	416	158	24	31	11,942	10,928	.915	1,014	2.45	31	24868
13	Martin Biron M. Biron	198	424	401	158	24	20	11,711	10,678	.912	1,033	2.58	25	24025
14	Dominik Hasek D. Hasek	194	321	318	84	20	13	8,007	7,336	.916	671	2.13	39	18934
15	Patrick Lalime P. Lalime	175	382	362	149	30	14	9,609	8,683	.904	926	2.53	32	21964
16	Manny Legace M. Legace	175	320	299	83	16	18	7,967	7,266	.912	701	2.37	23	17769
17	Nikolai Khabibulin N. Khabibulin	173	394	382	154	28	24	10,785	9,800	.909	985	2.61	20	22679
18	Ryan Miller R. Miller	146	264	260	86	1	25	7,686	6,997	.910	689	2.66	12	15562
19	Henrik Lundqvist H. Lundqvist	142	265	261	83		34	7,242	6,638	.917	604	2.31	20	15678
20	Manny Fernandez M. Fernandez	142	316	302	120	23	11	8,591	7,842	.913	749	2.48	15	18143
21	Dwayne Roloson D. Roloson	141	374	349	160	29	25	10,448	9,537	.913	911	2.56	21	21368
22	Tommy Salo T. Salo	140	326	318	129	50		8,312	7,531	.906	781	2.44	23	19168
23	Patrick Roy P. Roy	139	251	247	72	36		6,505	5,973	.918	532	2.15	20	14831
24	Dan Cloutier D. Cloutier	129	317	296	129	29	4	7,807	7,005	.897	802	2.78	15	17281
25	Roman Turek R. Turek	129	273	270	101	39		6,699	6,071	.906	628	2.34	25	16127