Between the 2019-20 and 2028-29 seasons, the Colorado Avalanche had the most wins by a team, with 310 wins.

Interpreted as:

most regular-season wins by NHL team in the 2020s

	TEAM	W	GP	L	OTL	PTS	PTS%	SOW	SOL	G	GA	DIFF	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Avalanche	310	486	132	44	664	.683	17	16	1,718	1,330	388	22.8	80.7	33.05	10.7	29.24	.906
2	Hurricanes	300	484	140	44	644	.665	20	16	1,578	1,267	311	21.9	85.0	33.25	9.8	26.73	.902
3	Bruins	292	487	141	54	638	.655	16	18	1,537	1,290	247	21.6	82.8	31.30	10.1	29.33	.910
4	Maple Leafs	287	485	145	53	627	.646	12	13	1,680	1,433	247	23.9	79.5	31.60	11.0	30.00	.902
5	Panthers	287	484	158	39	613	.633	19	14	1,649	1,408	241	22.6	79.7	34.20	10.0	29.50	.901
6	Lightning	286	486	158	42	614	.632	13	15	1,672	1,384	288	24.6	81.9	30.16	11.4	29.59	.904
7	Golden Knights	284	486	148	54	622	.640	19	22	1,575	1,344	231	21.4	78.8	32.18	10.1	28.81	.904
8	Oilers	283	488	162	43	609	.624	9	11	1,677	1,459	218	27.9	79.8	32.08	10.7	29.93	.900
9	Stars	276	486	148	62	614	.632	22	20	1,525	1,322	203	23.7	81.2	30.16	10.4	29.51	.908
10	Jets	275	486	177	34	584	.601	9	12	1,508	1,313	195	21.6	78.6	30.14	10.3	30.42	.911
11	Rangers	273	487	169	45	591	.607	16	13	1,552	1,364	188	22.9	81.3	29.88	10.7	30.36	.908
12	Wild	272	486	162	52	596	.613	24	21	1,511	1,426	85	21.1	77.2	29.89	10.4	30.45	.904
13	Capitals	265	485	161	59	589	.607	20	24	1,555	1,436	119	20.8	81.1	29.60	10.8	29.33	.899
14	Blues	254	488	176	58	566	.580	18	18	1,527	1,489	38	22.0	77.8	28.74	10.9	30.35	.899
15	Penguins	249	484	171	64	562	.581	13	23	1,538	1,462	76	21.5	80.6	31.91	10.0	30.66	.901
16	Kings	247	485	175	63	557	.574	16	24	1,413	1,354	59	19.5	79.8	31.40	9.3	28.18	.901
17	Flames	242	487	184	61	545	.560	18	17	1,463	1,425	38	19.8	81.1	32.27	9.3	29.17	.900
18	Predators	242	484	200	42	526	.543	25	7	1,411	1,485	-74	20.1	79.2	30.44	9.6	31.05	.901
19	Islanders	239	485	179	67	545	.562	16	28	1,376	1,368	8	17.7	79.3	29.63	9.6	30.73	.908
20	Canucks	237	485	193	55	529	.545	21	15	1,487	1,512	-25	22.3	77.5	29.11	10.5	30.46	.898
21	Devils	224	486	213	49	497	.511	13	24	1,463	1,541	-78	20.4	80.1	30.66	9.8	29.64	.893
22	Senators	216	486	223	47	479	.493	17	11	1,415	1,576	-161	20.0	77.6	30.66	9.5	31.00	.895
23	Flyers	209	484	209	66	484	.500	26	22	1,367	1,585	-218	15.7	78.2	29.97	9.4	29.38	.889
24	Sabres	208	485	227	50	466	.480	20	14	1,454	1,634	-180	20.1	76.9	29.79	10.1	31.28	.892
25	Red Wings	201	488	232	55	457	.468	19	14	1,343	1,657	-314	19.9	76.2	28.24	9.7	31.31	.892