Nathan MacKinnon has 13 goals, 18 assists and a plus-minus of +15 in 19 games against the Sabres in his career.

	NAME	DATE	TM		OPP	G	A	P	+/-	PIM	PPG	PPA	GWG	S	S%	FOW	FO	FOW%	HIT	BKS	TKA	GVA	TOI
1	Nathan MacKinnon N. MacKinnon	10/19/2013	COL	@	BUF	0	0	0	0	0	0	0	0	1	0.0	5	10	50.0	0	0	0	1	13:58
2	Nathan MacKinnon N. MacKinnon	2/1/2014	COL	vs	BUF	1	2	3	+3	0	1	0	0	4	25.0	8	12	66.7	1	1	0	0	16:48
3	Nathan MacKinnon N. MacKinnon	12/20/2014	COL	@	BUF	0	1	1	+1	0	0	0	0	3	0.0	2	2	100.0	0	0	0	0	14:46
4	Nathan MacKinnon N. MacKinnon	1/20/2016	COL	vs	BUF	0	0	0	+2	0	0	0	0	3	0.0	7	11	63.6	1	0	0	0	21:46
5	Nathan MacKinnon N. MacKinnon	2/14/2016	COL	@	BUF	0	0	0	0	0	0	0	0	3	0.0	7	16	43.8	0	0	0	0	20:09
6	Nathan MacKinnon N. MacKinnon	2/16/2017	COL	@	BUF	0	0	0	0	0	0	0	0	0		9	22	40.9	0	1	0	0	21:31
7	Nathan MacKinnon N. MacKinnon	2/25/2017	COL	vs	BUF	0	2	2	+2	0	0	0	0	3	0.0	7	13	53.8	0	0	1	1	17:54
8	Nathan MacKinnon N. MacKinnon	12/5/2017	COL	vs	BUF	2	0	2	-3	0	2	0	0	7	28.6	10	16	62.5	0	0	0	1	21:48
9	Nathan MacKinnon N. MacKinnon	10/11/2018	COL	@	BUF	2	0	2	+2	2	0	0	0	4	50.0	7	14	50.0	0	0	0	2	19:20
10	Nathan MacKinnon N. MacKinnon	3/9/2019	COL	vs	BUF	1	2	3	+2	0	0	1	1	3	33.3	8	10	80.0	2	0	0	2	22:23
11	Nathan MacKinnon N. MacKinnon	2/4/2020	COL	@	BUF	0	1	1	0	0	0	0	0	4	0.0	5	10	50.0	2	0	1	1	19:36
12	Nathan MacKinnon N. MacKinnon	2/26/2020	COL	vs	BUF	0	1	1	0	0	0	1	0	2	0.0	3	7	42.9	1	0	0	1	22:22
13	Nathan MacKinnon N. MacKinnon	2/19/2022	COL	@	BUF	1	0	1	+1	0	0	0	0	5	20.0	4	8	50.0	1	0	0	0	20:16
14	Nathan MacKinnon N. MacKinnon	12/1/2022	COL	@	BUF	2	3	5	+1	2	1	2	0	8	25.0	8	18	44.4	0	2	0	0	25:09
15	Nathan MacKinnon N. MacKinnon	10/29/2023	COL	@	BUF	0	0	0	-2	12	0	0	0	4	0.0	2	10	20.0	0	0	2	3	18:23
16	Nathan MacKinnon N. MacKinnon	12/13/2023	COL	vs	BUF	0	2	2	+1	0	0	1	0	2	0.0	10	18	55.6	2	0	0	1	20:53
17	Nathan MacKinnon N. MacKinnon	12/3/2024	COL	@	BUF	2	1	3	+1	0	0	0	0	9	22.2	7	19	36.8	2	2	0	1	23:33
18	Nathan MacKinnon N. MacKinnon	1/2/2025	COL	vs	BUF	0	3	3	+2	0	0	1	0	3	0.0	14	27	51.9	1	1	2	2	26:16
19	Nathan MacKinnon N. MacKinnon	10/13/2025	COL	@	BUF	2	0	2	+2	0	0	0	0	5	40.0	10	17	58.8	0	1	1	2	21:47
	Total					13	18	31	+15	16	4	6	1	73	17.8	133	260	51.2	13	8	7	18	388:38