Since 1999-00, the Boston Bruins have the most wins by a team, with 1,053 wins.

Interpreted as:

NHL most regular-season wins since 2000

	TEAM	W	GP	L	T	OTL	PTS	PTS%	SOW	SOL	G	GA	DIFF	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Bruins	1,053	1,978	640	59	226	2,391	.604	78	91	5,757	5,173	584	18.8	83.0	31.37	9.3	29.36	.911
2	Stars	1,046	1,977	675	59	197	2,348	.594	88	71	5,653	5,247	406	18.8	82.3	29.31	9.8	28.46	.907
3	Capitals	1,042	1,977	679	51	205	2,340	.592	81	86	5,914	5,573	341	20.3	81.6	29.40	10.2	30.07	.906
4	Avalanche	1,034	1,978	722	55	167	2,290	.579	89	52	5,868	5,499	369	19.6	81.5	30.08	9.9	29.88	.907
5	Blues	1,031	1,979	696	53	199	2,314	.585	88	79	5,622	5,287	335	18.7	82.9	29.19	9.7	27.86	.904
6	Red Wings	1,021	1,979	688	50	220	2,312	.584	83	83	5,773	5,532	241	20.1	81.9	30.82	9.5	28.97	.904
7	Penguins	1,019	1,977	722	39	197	2,274	.575	90	71	5,977	5,755	222	19.7	81.8	30.49	9.9	30.40	.904
8	Rangers	1,002	1,978	755	38	183	2,225	.562	92	77	5,652	5,412	240	18.3	82.1	30.18	9.5	30.08	.909
9	Maple Leafs	998	1,978	729	45	206	2,247	.568	69	84	5,984	5,804	180	19.4	80.5	30.15	10.0	30.32	.903
10	Lightning	998	1,978	750	50	180	2,226	.563	78	70	5,919	5,767	152	19.4	81.6	29.40	10.2	29.68	.902
11	Predators	988	1,977	745	53	191	2,220	.561	89	74	5,429	5,385	44	17.3	82.2	29.35	9.4	29.96	.909
12	Canucks	987	1,977	733	56	201	2,231	.564	84	87	5,655	5,482	173	18.9	82.0	29.28	9.8	29.55	.906
13	Devils	982	1,977	746	51	198	2,213	.560	85	97	5,333	5,249	84	18.3	83.1	29.60	9.1	27.94	.905
14	Sharks	971	1,978	743	51	213	2,206	.558	83	86	5,559	5,522	37	19.2	82.4	30.19	9.3	29.10	.904
15	Hurricanes	965	1,976	748	60	203	2,193	.555	57	74	5,536	5,509	27	17.6	82.8	31.18	9.0	28.54	.902
16	Senators	965	1,979	772	47	195	2,172	.549	69	84	5,798	5,678	120	18.6	81.9	30.69	9.5	30.17	.905
17	Kings	954	1,978	760	58	206	2,172	.549	82	86	5,377	5,306	71	18.0	81.5	30.01	9.1	27.99	.904
18	Flyers	953	1,977	735	61	228	2,195	.555	66	103	5,650	5,647	3	18.2	81.6	30.48	9.4	29.11	.902
19	Flames	951	1,978	773	57	197	2,156	.545	61	78	5,488	5,530	-42	17.5	81.6	29.72	9.3	28.79	.903
20	Wild	942	1,895	709	55	189	2,128	.561	89	86	5,112	5,029	83	17.8	82.4	28.16	9.6	29.65	.911
21	Ducks	925	1,979	783	50	221	2,121	.536	83	90	5,223	5,553	-330	17.9	81.5	28.85	9.1	30.52	.908
22	Canadiens	917	1,979	799	44	219	2,097	.530	83	82	5,379	5,633	-254	18.1	81.6	29.10	9.3	30.82	.908
23	Jets	917	1,979	840	45	177	2,056	.519	78	66	5,631	5,971	-340	17.8	79.9	29.19	9.7	31.29	.904
24	Oilers	906	1,979	817	63	193	2,068	.522	82	76	5,601	5,805	-204	18.8	81.2	29.17	9.7	29.95	.902
25	Panthers	905	1,977	783	57	232	2,099	.531	85	104	5,494	5,681	-187	17.8	81.4	31.00	9.0	31.50	.909