Between the 2019-20 and 2028-29 seasons, the Colorado Avalanche had the most wins by a team, with 292 wins.

Interpreted as:

NHL team most regular-season wins 2020s

	TEAM	W	GP	L	OTL	PTS	PTS%	SOW	SOL	G	GA	DIFF	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Avalanche	292	460	130	38	622	.676	17	13	1,611	1,269	342	23.1	80.4	32.94	10.6	29.33	.906
2	Hurricanes	284	458	132	42	610	.666	16	15	1,498	1,193	305	22.2	85.4	33.30	9.8	26.86	.903
3	Maple Leafs	276	460	135	49	601	.653	12	12	1,600	1,352	248	24.3	79.3	31.87	10.9	29.87	.902
4	Bruins	276	461	131	54	606	.657	14	18	1,451	1,207	244	21.2	83.1	31.52	10.0	29.23	.910
5	Panthers	274	460	149	37	585	.636	18	13	1,567	1,330	237	22.8	79.6	34.44	9.9	29.63	.902
6	Golden Knights	273	462	142	47	593	.642	18	20	1,510	1,276	234	21.3	78.5	32.34	10.1	29.02	.905
7	Oilers	270	461	153	38	578	.627	9	10	1,582	1,364	218	27.6	79.8	32.28	10.6	30.08	.902
8	Lightning	269	460	150	41	579	.629	13	14	1,584	1,323	261	25.0	81.8	30.23	11.4	29.78	.903
9	Jets	265	461	163	33	563	.611	8	11	1,436	1,231	205	21.8	79.0	30.28	10.3	30.54	.913
10	Rangers	260	462	160	42	562	.608	15	13	1,481	1,291	190	22.9	81.4	30.11	10.6	30.43	.908
11	Stars	258	458	143	57	573	.626	20	18	1,435	1,253	182	23.2	80.9	30.48	10.3	29.64	.908
12	Wild	256	460	156	48	560	.609	22	20	1,434	1,363	71	21.2	77.0	30.00	10.4	30.48	.903
13	Capitals	251	459	153	55	557	.607	20	20	1,466	1,369	97	21.1	81.4	29.64	10.8	29.42	.899
14	Blues	245	460	164	51	541	.588	18	16	1,458	1,391	67	22.1	77.8	28.97	10.9	30.46	.901
15	Penguins	239	459	165	55	533	.581	13	18	1,457	1,386	71	20.8	80.3	32.07	9.9	30.76	.902
16	Kings	234	460	170	56	524	.570	16	20	1,347	1,300	47	20.0	79.6	31.59	9.3	28.30	.900
17	Predators	232	459	187	40	504	.549	23	7	1,341	1,395	-54	20.1	79.0	30.57	9.6	31.18	.903
18	Flames	230	461	174	57	517	.561	17	15	1,392	1,357	35	20.1	80.8	32.37	9.3	29.24	.899
19	Canucks	229	459	178	52	510	.556	20	15	1,419	1,417	2	22.4	77.9	29.23	10.6	30.57	.899
20	Islanders	222	457	171	64	508	.556	13	25	1,295	1,297	-2	17.8	78.7	29.70	9.5	30.89	.908
21	Devils	210	458	200	48	468	.511	11	24	1,387	1,453	-66	20.4	80.7	30.72	9.9	29.70	.893
22	Senators	204	461	214	43	451	.489	15	11	1,339	1,504	-165	19.7	77.8	30.88	9.4	31.31	.896
23	Flyers	196	459	202	61	453	.493	21	20	1,298	1,515	-217	15.6	78.0	30.20	9.4	29.57	.888
24	Sabres	196	459	217	46	438	.477	18	14	1,373	1,543	-170	20.1	76.7	29.88	10.0	31.41	.893
25	Red Wings	188	461	221	52	428	.464	17	12	1,261	1,564	-303	19.7	76.1	28.12	9.7	31.49	.892