The Montreal Canadiens have the highest goal differential by a team when playing 75+ games, with a differential of 2,593 goals.

NHL team with best 5 on 5 or more scoring differential we are about 75 or more games in

	TEAM	DIFF	GP	W	PTS	PTS%	G	GA	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Canadiens	2,593	429	429	858	1.000	3,179	586	39.2	88.5	36.38	20.0	25.91	.951
2	Bruins	2,006	337	337	674	1.000	2,420	414	40.1	90.8	35.94	19.9	25.72	.952
3	Maple Leafs	1,831	309	309	618	1.000	2,221	390	37.7	94.1	35.53	19.6	29.88	.963
4	Red Wings	1,743	294	294	588	1.000	2,098	355	35.2	90.8	35.32	20.1	25.47	.950
5	Rangers	1,638	287	287	574	1.000	1,998	360	36.6	89.7	35.09	19.8	27.81	.954
6	Blackhawks	1,487	260	260	520	1.000	1,818	331	34.2	88.7	34.01	20.4	28.76	.957
7	Flyers	1,197	204	204	408	1.000	1,446	249	36.7	90.6	36.13	19.6	26.89	.955
8	Sabres	1,124	195	195	390	1.000	1,401	277	35.9	91.6	34.92	20.6	26.74	.947
9	Penguins	1,102	192	192	384	1.000	1,385	283	40.1	90.7	35.57	20.3	29.07	.949
10	Flames	1,075	181	181	362	1.000	1,352	277	38.2	89.2	35.41	21.1	27.20	.944
11	Islanders	1,007	170	170	340	1.000	1,237	230	34.6	90.9	33.54	21.7	28.20	.952
12	Oilers	981	167	167	334	1.000	1,270	289	36.3	88.7	33.54	22.7	30.02	.942
13	Kings	978	169	169	338	1.000	1,222	244	37.2	88.9	35.27	20.5	27.78	.948
14	Blues	953	170	170	340	1.000	1,184	231	38.8	89.7	33.01	21.1	27.20	.950
15	Stars	863	151	151	302	1.000	1,065	202	40.3	91.8	34.51	20.4	27.95	.952
16	Capitals	801	137	137	274	1.000	981	180	39.4	90.9	33.25	21.5	27.76	.953
17	Avalanche	795	139	139	278	1.000	972	177	38.4	92.0	34.04	20.5	27.37	.953
18	Canucks	722	128	128	256	1.000	867	145	35.6	90.5	33.01	20.5	26.73	.958
19	Devils	580	105	105	210	1.000	698	118	36.7	90.1	34.08	19.5	25.64	.956
20	Hurricanes	488	85	85	170	1.000	607	119	39.7	89.6	33.59	21.3	27.16	.948
21	Coyotes	470	80	80	160	1.000	562	92	30.7	89.6	33.34	21.1	29.18	.961