Gilbert Perreault has the most career assists for the Sabres, with 814 assists.

	NAME	A	GP	G	P	+/-	PIM	PPG	PPA	SHG	SHA	GWG	OTG	S	S%	FOW	FO	FOW%	HIT	BKS	TKA	GVA	TOI/GP
1	Gilbert Perreault G. Perreault	814	1,191	512	1,326	+41	500	134	298	8	4	81	0	3,077	16.6
2	Dave Andreychuk D. Andreychuk	436	837	368	804	+22	592	161	180	0	0	38	4	2,342	15.7	93	187	49.7	36	25	31	36	12:00
3	Craig Ramsay C. Ramsay	420	1,070	252	672	+324	201	17	48	27	20	32	0	1,617	15.6
4	Phil Housley P. Housley	380	608	178	558	+3	386	61	189	4	2	25	3	1,597	11.1
5	Rene Robert R. Robert	330	524	222	552	+47	401	53	144	0	0	32		1,754	12.7
6	Richard Martin R. Martin	313	681	382	695	+12	475	114	103	0	0	47		2,515	15.2
7	Don Luce D. Luce	310	766	216	526	+214	304	22	22	25	18	30		1,774	12.2
8	Jason Pominville J. Pominville	304	733	217	521	+20	159	48	106	10	5	24	5	1,908	11.4	436	981	44.4	332	405	337	277	17:35
9	Rasmus Dahlin R. Dahlin	292	528	84	376	-62	390	29	121	0	2	13	3	1,236	6.8	0	0		784	661	229	458	23:19
10	Dale Hawerchuk D. Hawerchuk	275	342	110	385	-29	204	48	145	1	0	16	0	978	11.2
11	Derek Roy D. Roy	266	549	161	427	+39	331	45	92	8	3	30	6	1,271	12.7	4,266	8,595	49.6	272	311	346	457	19:05
12	Mike Foligno M. Foligno	264	664	247	511	+115	1,448	62	61	2	4	42	1	1,450	17.0
13	Mike Ramsey M. Ramsey	256	911	73	329	+166	924	12	52	2	9	15	1	1,323	5.5
14	Thomas Vanek T. Vanek	243	598	254	497	+29	362	106	78	3	0	41	6	1,685	15.1	46	139	33.1	257	166	271	446	16:48
15	Alexei Zhitnik A. Zhitnik	234	712	55	289	-33	822	23	119	5	10	7	0	1,482	3.7	0	1	0.0	624	369	89	315	25:14
16	Alexander Mogilny A. Mogilny	233	381	211	444	+44	203	78	88	3	4	29	0	1,333	15.8
17	Doug Bodger D. Bodger	233	479	54	287	+15	506	33	144	1	7	4	0	1,032	5.2
18	Danny Gare D. Gare	233	503	267	500	+187	686	66	58	1	1	35		1,780	15.0
19	Miroslav Satan M. Satan	232	578	224	456	+44	233	74	75	15	7	33	2	1,560	14.4	11	41	26.8	140	136	188	351	20:37
20	Christian Ruuttu C. Ruuttu	230	438	101	331	+16	483	22	68	8	6	10	0	925	10.9
21	Pat LaFontaine P. LaFontaine	227	268	158	385	+3	207	66	111	6	0	22	0	865	18.3
22	Tim Connolly T. Connolly	226	464	94	320	-2	174	37	96	3	5	24	2	980	9.6	2,407	5,516	43.6	150	274	168	285	17:34
23	Jack Eichel J. Eichel	216	375	139	355	-69	142	41	86	1	2	25	8	1,324	10.5	2,465	5,585	44.1	251	203	205	309	20:19
24	Jerry Korab J. Korab	216	537	67	283	+78	870	24	78	3	5	8	0	1,185	5.7
25	Jochen Hecht J. Hecht	207	613	138	345	+67	322	20	36	7	5	17	2	1,602	8.6	1,548	3,622	42.7	297	303	264	314	17:44