Since 2005-06, the Buffalo Sabres have their most wins in a season in 2006-07, with 53 wins.

	TEAM	W	SEASON	GP	L	OTL	PTS	PTS%	SOW	SOL	G	GA	DIFF	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Sabres	53	2006-07	82	22	7	113	.689	10	4	298	238	60	17.4	81.3	29.48	12.3	31.00	.906
2	Sabres	52	2005-06	82	24	6	110	.671	5	5	276	234	42	21.2	86.6	30.61	11.0	30.51	.906
3	Sabres	45	2009-10	82	27	10	100	.610	4	6	231	201	30	17.6	86.6	31.56	8.9	31.38	.922
4	Sabres	43	2010-11	82	29	10	96	.585	5	1	240	228	12	19.4	83.0	32.80	8.9	30.66	.909
5	Sabres	42	2022-23	82	33	7	91	.555	3	3	293	297	-4	23.4	73.0	32.50	11.0	33.05	.890
6	Sabres	41	2008-09	82	32	9	91	.555	8	5	242	229	13	20.9	81.8	30.55	9.7	31.40	.911
7	Sabres	39	2023-24	82	37	6	84	.512	2	1	244	243	1	16.6	79.8	30.90	9.6	29.28	.899
8	Sabres	39	2011-12	82	32	11	89	.543	7	7	211	223	-12	17.1	81.7	29.23	8.8	31.35	.913
9	Sabres	39	2007-08	82	31	12	90	.549	4	9	251	233	18	18.0	83.2	30.22	10.1	28.37	.900
10	Sabres	36	2024-25	82	39	7	79	.482	4	2	265	287	-22	18.8	76.3	27.78	11.6	28.88	.879
11	Sabres	35	2015-16	82	36	11	81	.494	2	7	199	215	-16	18.9	82.6	29.49	8.2	30.62	.914
12	Sabres	33	2018-19	82	39	10	76	.463	5	3	221	268	-47	19.5	80.9	32.89	8.2	32.98	.901
13	Sabres	33	2016-17	82	37	12	78	.476	2	6	199	231	-32	24.5	77.6	30.38	8.0	34.30	.918
14	Sabres	32	2021-22	82	39	11	75	.457	3	3	229	287	-58	21.2	76.4	29.89	9.3	32.95	.894
15	Sabres	30	2019-20	69	31	8	68	.493	2	2	193	215	-22	18.9	74.6	29.29	9.5	31.13	.900
16	Sabres	25	2017-18	82	45	12	62	.378	1	2	198	278	-80	18.9	77.9	31.18	7.7	32.70	.896
17	Sabres	23	2014-15	82	51	8	54	.329	8	5	153	269	-116	13.4	75.1	24.20	7.7	35.61	.908
18	Sabres	21	2013-14	82	51	10	52	.317	7	5	150	243	-93	14.1	81.4	26.29	7.0	34.34	.914
19	Sabres	21	2012-13	48	21	6	48	.500	7	4	118	139	-21	14.1	79.2	27.90	8.8	33.46	.913
20	Sabres	15	2020-21	56	34	7	37	.330	4	3	134	196	-62	21.0	77.7	28.43	8.4	33.73	.896
21	Sabres	11	2025-26	28	13	4	26	.464	2	0	82	96	-14	18.1	87.2	29.00	10.1	30.00	.886