Since 1999-00, the Columbus Blue Jackets have lost the most games by a team, with 860 losses.

Interpreted as:

team with most series regular-season losses since 2000

	TEAM	L	GP	W	T	OTL	PTS	PTS%	SOW	SOL	G	GA	DIFF	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Blue Jackets	860	1,896	807	33	196	1,843	.486	85	79	4,993	5,731	-738	16.1	81.1	29.05	9.1	31.14	.903
2	Sabres	858	1,977	877	44	198	1,996	.505	93	83	5,399	5,782	-383	17.6	81.8	29.41	9.3	30.87	.905
3	Jets	840	1,979	917	45	177	2,056	.519	78	66	5,631	5,971	-340	17.8	79.9	29.19	9.7	31.29	.904
4	Coyotes	836	1,896	806	63	191	1,866	.492	84	79	4,915	5,583	-668	16.6	80.4	28.45	9.1	31.34	.906
5	Islanders	828	1,976	889	46	213	2,037	.515	92	89	5,387	5,827	-440	16.9	80.7	29.65	9.2	30.77	.904
6	Blackhawks	823	1,978	891	55	209	2,046	.517	86	79	5,499	5,833	-334	17.0	81.2	29.80	9.3	30.06	.902
7	Oilers	817	1,979	906	63	193	2,068	.522	82	76	5,601	5,805	-204	18.8	81.2	29.17	9.7	29.95	.902
8	Canadiens	799	1,979	917	44	219	2,097	.530	83	82	5,379	5,633	-254	18.1	81.6	29.10	9.3	30.82	.908
9	Ducks	783	1,979	925	50	221	2,121	.536	83	90	5,223	5,553	-330	17.9	81.5	28.85	9.1	30.52	.908
10	Panthers	783	1,977	905	57	232	2,099	.531	85	104	5,494	5,681	-187	17.8	81.4	31.00	9.0	31.50	.909
11	Flames	773	1,978	951	57	197	2,156	.545	61	78	5,488	5,530	-42	17.5	81.6	29.72	9.3	28.79	.903
12	Senators	772	1,979	965	47	195	2,172	.549	69	84	5,798	5,678	120	18.6	81.9	30.69	9.5	30.17	.905
13	Kings	760	1,978	954	58	206	2,172	.549	82	86	5,377	5,306	71	18.0	81.5	30.01	9.1	27.99	.904
14	Rangers	755	1,978	1,002	38	183	2,225	.562	92	77	5,652	5,412	240	18.3	82.1	30.18	9.5	30.08	.909
15	Lightning	750	1,978	998	50	180	2,226	.563	78	70	5,919	5,767	152	19.4	81.6	29.40	10.2	29.68	.902
16	Hurricanes	748	1,976	965	60	203	2,193	.555	57	74	5,536	5,509	27	17.6	82.8	31.18	9.0	28.54	.902
17	Devils	746	1,977	982	51	198	2,213	.560	85	97	5,333	5,249	84	18.3	83.1	29.60	9.1	27.94	.905
18	Predators	745	1,977	988	53	191	2,220	.561	89	74	5,429	5,385	44	17.3	82.2	29.35	9.4	29.96	.909
19	Sharks	743	1,978	971	51	213	2,206	.558	83	86	5,559	5,522	37	19.2	82.4	30.19	9.3	29.10	.904
20	Flyers	735	1,977	953	61	228	2,195	.555	66	103	5,650	5,647	3	18.2	81.6	30.48	9.4	29.11	.902
21	Canucks	733	1,977	987	56	201	2,231	.564	84	87	5,655	5,482	173	18.9	82.0	29.28	9.8	29.55	.906
22	Maple Leafs	729	1,978	998	45	206	2,247	.568	69	84	5,984	5,804	180	19.4	80.5	30.15	10.0	30.32	.903
23	Penguins	722	1,977	1,019	39	197	2,274	.575	90	71	5,977	5,755	222	19.7	81.8	30.49	9.9	30.40	.904
24	Avalanche	722	1,978	1,034	55	167	2,290	.579	89	52	5,868	5,499	369	19.6	81.5	30.08	9.9	29.88	.907
25	Wild	709	1,895	942	55	189	2,128	.561	89	86	5,112	5,029	83	17.8	82.4	28.16	9.6	29.65	.911