Since 1999-00, the Columbus Blue Jackets have lost the most games by a team, with 864 losses.

Interpreted as:

team with most series regular-season losses since 2000

	TEAM	L	GP	W	T	OTL	PTS	PTS%	SOW	SOL	G	GA	DIFF	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Blue Jackets	864	1,906	813	33	196	1,855	.487	86	79	5,027	5,762	-735	16.1	81.0	29.07	9.1	31.15	.903
2	Sabres	862	1,987	881	44	200	2,006	.505	93	83	5,429	5,813	-384	17.7	81.9	29.41	9.3	30.88	.905
3	Jets	843	1,989	924	45	177	2,070	.520	78	66	5,665	5,996	-331	17.8	79.9	29.17	9.8	31.29	.904
4	Coyotes	836	1,896	806	63	191	1,866	.492	84	79	4,915	5,583	-668	16.6	80.4	28.45	9.1	31.34	.906
5	Islanders	832	1,985	893	46	214	2,046	.515	92	90	5,419	5,859	-440	16.8	80.7	29.65	9.2	30.77	.904
6	Blackhawks	826	1,988	896	55	211	2,058	.518	86	80	5,532	5,858	-326	17.0	81.2	29.77	9.3	30.05	.902
7	Oilers	821	1,990	911	63	195	2,080	.523	82	77	5,636	5,839	-203	18.8	81.2	29.16	9.7	29.91	.902
8	Canadiens	802	1,990	925	44	219	2,113	.531	83	82	5,419	5,666	-247	18.1	81.6	29.08	9.4	30.79	.908
9	Panthers	788	1,988	910	57	233	2,110	.531	85	105	5,521	5,711	-190	17.8	81.4	30.99	9.0	31.46	.909
10	Ducks	786	1,988	930	50	222	2,132	.536	84	90	5,254	5,584	-330	17.9	81.4	28.87	9.2	30.53	.908
11	Flames	781	1,989	953	57	198	2,161	.543	62	78	5,511	5,569	-58	17.5	81.5	29.71	9.3	28.80	.903
12	Senators	777	1,990	970	47	196	2,183	.548	70	84	5,838	5,722	116	18.7	81.8	30.68	9.6	30.14	.905
13	Kings	763	1,989	959	58	209	2,185	.549	83	88	5,409	5,340	69	18.0	81.5	30.00	9.1	27.99	.904
14	Rangers	760	1,989	1,006	38	185	2,235	.562	92	77	5,676	5,438	238	18.3	82.2	30.17	9.5	30.06	.909
15	Lightning	754	1,988	1,002	50	182	2,236	.562	78	70	5,948	5,797	151	19.4	81.6	29.38	10.2	29.68	.902
16	Hurricanes	751	1,985	971	60	203	2,205	.555	58	74	5,569	5,537	32	17.5	82.8	31.19	9.0	28.54	.902
17	Predators	750	1,988	992	53	193	2,230	.561	90	74	5,456	5,422	34	17.3	82.2	29.34	9.4	29.96	.909
18	Sharks	749	1,988	973	51	215	2,212	.556	83	86	5,591	5,568	23	19.2	82.4	30.17	9.3	29.11	.904
19	Devils	748	1,987	990	51	198	2,229	.561	85	97	5,372	5,279	93	18.4	83.1	29.60	9.1	27.94	.905
20	Canucks	739	1,988	992	56	201	2,241	.564	85	87	5,683	5,515	168	18.9	82.0	29.26	9.8	29.55	.906
21	Flyers	738	1,986	958	61	229	2,206	.555	68	103	5,674	5,670	4	18.2	81.7	30.45	9.4	29.10	.902
22	Maple Leafs	734	1,989	1,003	45	207	2,258	.568	69	84	6,022	5,846	176	19.4	80.5	30.14	10.0	30.31	.903
23	Penguins	724	1,988	1,026	39	199	2,290	.576	90	73	6,017	5,783	234	19.7	81.8	30.47	9.9	30.41	.904
24	Avalanche	723	1,989	1,040	55	171	2,306	.580	89	54	5,909	5,527	382	19.5	81.5	30.11	9.9	29.85	.907
25	Wild	714	1,906	945	55	192	2,137	.561	90	86	5,142	5,072	70	17.9	82.3	28.17	9.6	29.65	.910