Since 2020-21, the Colorado Avalanche have the most wins by a team, with 268 wins.

Interpreted as:

team with the most NHL regular-season wins since 2021

	TEAM	W	GP	L	OTL	PTS	PTS%	SOW	SOL	G	GA	DIFF	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Avalanche	268	416	112	36	572	.688	16	15	1,482	1,140	342	23.4	80.6	33.19	10.7	28.89	.905
2	Hurricanes	261	415	115	39	561	.676	14	16	1,359	1,072	287	21.8	85.2	33.26	9.8	26.31	.902
3	Panthers	252	415	132	31	535	.645	16	10	1,421	1,184	237	22.7	79.8	34.46	9.9	29.04	.902
4	Maple Leafs	251	415	120	44	546	.658	11	8	1,443	1,211	232	24.0	79.7	31.39	11.1	29.68	.902
5	Bruins	248	416	126	42	538	.647	16	11	1,308	1,117	191	21.0	82.6	31.17	10.1	29.21	.908
6	Oilers	246	416	136	34	526	.632	7	9	1,453	1,240	213	27.7	79.1	32.52	10.7	29.58	.899
7	Golden Knights	245	415	124	46	536	.646	16	20	1,351	1,135	216	21.3	79.3	31.78	10.2	28.72	.905
8	Lightning	243	416	137	36	522	.627	11	14	1,429	1,190	239	24.8	82.0	30.00	11.4	29.36	.903
9	Stars	239	417	124	54	532	.638	20	17	1,347	1,148	199	24.1	81.5	30.08	10.7	29.17	.906
10	Jets	238	415	149	28	504	.607	6	10	1,295	1,112	183	21.8	78.8	29.94	10.4	30.05	.911
11	Rangers	236	417	141	40	512	.614	15	11	1,319	1,144	175	22.9	82.0	29.68	10.7	29.74	.908
12	Wild	236	416	135	45	517	.621	22	18	1,287	1,207	80	21.0	77.1	29.85	10.4	30.42	.905
13	Capitals	224	416	141	51	499	.600	16	21	1,319	1,224	95	21.1	80.8	29.20	10.9	29.19	.899
14	Kings	218	415	140	57	493	.594	15	21	1,236	1,145	91	19.9	80.1	31.09	9.6	27.93	.901
15	Blues	212	417	157	48	472	.566	16	15	1,304	1,299	5	21.6	77.5	28.41	11.0	30.48	.898
16	Penguins	209	414	148	57	475	.574	10	23	1,313	1,261	52	21.8	80.3	31.94	9.9	30.80	.901
17	Predators	207	415	174	34	448	.540	22	4	1,199	1,271	-72	20.6	79.7	30.00	9.6	31.01	.901
18	Flames	206	417	157	54	466	.559	12	16	1,259	1,211	48	19.5	81.0	32.39	9.3	28.62	.899
19	Islanders	204	417	156	57	465	.558	13	25	1,187	1,178	9	17.8	79.0	29.63	9.6	30.65	.908
20	Canucks	200	415	166	49	449	.541	17	12	1,261	1,297	-36	21.9	77.0	28.80	10.6	30.00	.896
21	Devils	196	416	183	37	429	.516	9	18	1,277	1,315	-38	20.9	79.8	30.67	10.0	29.17	.892
22	Senators	191	415	189	35	417	.502	16	6	1,225	1,338	-113	20.9	77.9	30.67	9.6	30.56	.895
23	Red Wings	184	417	183	50	418	.501	16	12	1,201	1,392	-191	20.7	76.5	28.44	10.1	31.05	.893
24	Sabres	177	415	196	42	396	.477	18	12	1,258	1,418	-160	20.3	77.3	29.89	10.1	31.33	.891
25	Flyers	168	414	188	58	394	.476	21	16	1,138	1,392	-254	14.7	77.5	29.74	9.2	29.50	.886