Kurtis MacDermid had the fewest giveaways by a defenseman with 50+ games played in 2021-22, with 12 given away.

Interpreted as:

2021 - 2022 NHL giveaway leaders defenseman 50 or more games

	NAME	GVA	GP	SEASON	TM	G	A	P	+/-	PIM	PPG	PPA	SHG	SHA	GWG	OTG	S	S%	FOW	FO	HIT	BKS	TKA	TOI/GP
1	Kurtis MacDermid K. MacDermid	12	58	2021-22	COL	2	3	5	+1	89	0	0	0	0	0	0	46	4.3	0	0	105	22	5	7:24
2	Mark Borowiecki M. Borowiecki	14	57	2021-22	NSH	0	4	4	-9	151	0	0	0	0	0	0	45	0.0	0	0	196	79	7	13:07
3	Marcus Pettersson M. Pettersson	14	72	2021-22	PIT	2	17	19	+8	38	0	0	0	0	0	0	83	2.4	0	0	122	74	17	15:39
4	Jared Spurgeon J. Spurgeon	14	65	2021-22	MIN	10	30	40	+32	10	0	14	0	0	2	2	116	8.6	0	0	44	83	13	21:09
5	Connor Clifton C. Clifton	14	60	2021-22	BOS	2	8	10	-2	32	0	0	0	0	0	0	80	2.5	0	0	156	62	16	16:04
6	Cal Foote C. Foote	15	56	2021-22	TBL	2	7	9	+6	29	0	0	0	0	0	0	49	4.1	0	0	83	57	4	13:08
7	Erik Cernak E. Cernak	17	55	2021-22	TBL	1	12	13	+7	46	0	0	0	0	0	0	86	1.2	0	0	165	73	21	19:09
8	Patrik Nemeth P. Nemeth	18	63	2021-22	NYR	2	5	7	-9	28	0	0	0	0	1	0	52	3.8	0	0	115	102	11	16:38
9	Jan Rutta J. Rutta	18	76	2021-22	TBL	3	15	18	+25	47	0	0	0	0	0	0	86	3.5	0	0	93	71	6	16:23
10	Brad Hunt B. Hunt	19	50	2021-22	VAN	3	14	17	-3	12	0	2	0	0	0	0	67	4.5	0	0	22	48	11	15:15
11	Ben Hutton B. Hutton	19	58	2021-22	VGK	3	10	13	+7	32	0	0	0	0	0	0	78	3.8	0	0	49	72	16	15:28
12	Trevor van Riemsdyk T. van Riemsdyk	19	72	2021-22	WSH	1	16	17	-3	40	0	0	0	1	0	0	75	1.3	0	0	25	129	30	17:28
13	Jake Middleton J. Middleton	19	66	2021-22	TOT	4	10	14	+10	82	0	1	0	1	0	0	73	5.5	0	0	118	124	27	18:41
14	Robert Bortuzzo R. Bortuzzo	20	73	2021-22	STL	1	5	6	-4	36	0	0	0	0	0	0	47	2.1	0	0	135	98	8	13:44
15	Mark Pysyk M. Pysyk	20	68	2021-22	BUF	3	9	12	-4	16	0	0	0	0	0	0	64	4.7	0	0	41	85	21	17:49
16	Danny DeKeyser D. DeKeyser	21	59	2021-22	DET	0	11	11	-8	26	0	0	0	0	0	0	57	0.0	0	0	49	102	7	18:30
17	Jon Merrill J. Merrill	21	69	2021-22	MIN	4	16	20	+15	22	0	0	0	0	0	0	59	6.8	0	0	46	112	6	17:07
18	Chad Ruhwedel C. Ruhwedel	21	78	2021-22	PIT	4	9	13	+2	14	0	0	0	0	0	0	82	4.9	0	0	149	86	19	15:20
19	Simon Benoit S. Benoit	21	53	2021-22	ANA	1	4	5	-5	22	0	0	0	0	0	0	45	2.2	0	0	168	39	7	14:06
20	Joshua Brown J. Brown	22	52	2021-22	TOT	0	6	6	-7	37	0	0	0	0	0	0	45	0.0	0	0	118	62	9	14:13
21	Jake Walman J. Walman	22	51	2021-22	TOT	3	7	10	-3	10	0	1	0	0	0	0	87	3.4	0	0	47	58	9	14:01
22	Jake Bean J. Bean	23	67	2021-22	CBJ	7	18	25	-5	26	0	4	0	1	2	2	90	7.8	0	0	41	71	21	20:34
23	Robert Hagg R. Hagg	23	64	2021-22	TOT	1	8	9	-9	35	0	0	0	0	0	0	59	1.7	0	0	138	102	10	16:01
24	Nicolas Hague N. Hague	23	52	2021-22	VGK	4	10	14	+6	38	0	0	0	0	0	0	116	3.4	0	0	57	80	25	18:40
25	Gustav Lindstrom G. Lindstrom	23	63	2021-22	DET	1	12	13	-12	22	0	0	0	0	0	0	41	2.4	0	0	59	77	9	16:07