Between the 1999-00 and 2008-09 seasons, Martin Brodeur had the most games by a goalie, with 624 games.

Interpreted as:

most regular-season games played, 2000s, goalie

	NAME	GP	GS	W	L	T	OTL	SA	SV	SV%	GA	GAA	SHO	MIN
1	Martin Brodeur M. Brodeur	624	623	356	194	48	23	16,011	14,628	.914	1,383	2.22	65	37394
2	Roberto Luongo R. Luongo	544	526	230	232	33	31	16,430	15,101	.919	1,329	2.57	47	31038
3	Olie Kolzig O. Kolzig	520	513	230	212	42	24	15,184	13,773	.907	1,411	2.76	24	30667
4	Evgeni Nabokov E. Nabokov	492	482	249	162	29	27	12,589	11,465	.911	1,124	2.38	47	28297
5	Tomas Vokoun T. Vokoun	474	454	205	193	31	25	13,606	12,462	.916	1,144	2.52	30	27189
6	Jose Theodore J. Theodore	466	445	206	196	28	15	12,859	11,697	.910	1,162	2.61	27	26669
7	Marty Turco M. Turco	456	433	240	134	26	26	10,933	9,955	.911	978	2.26	36	25976
8	Jean-Sebastien Giguere J. Giguere	434	416	203	158	24	31	11,942	10,928	.915	1,014	2.45	31	24868
9	Chris Osgood C. Osgood	426	407	223	127	32	23	10,651	9,622	.903	1,029	2.55	26	24189
10	Martin Biron M. Biron	424	401	198	158	24	20	11,711	10,678	.912	1,033	2.58	25	24025
11	Curtis Joseph C. Joseph	419	397	206	156	29	6	11,126	10,083	.906	1,043	2.62	29	23898
12	Ed Belfour E. Belfour	413	404	208	146	36	14	10,862	9,864	.908	998	2.48	31	24144
13	Nikolai Khabibulin N. Khabibulin	394	382	173	154	28	24	10,785	9,800	.909	985	2.61	20	22679
14	Miikka Kiprusoff M. Kiprusoff	385	371	204	125	7	35	10,454	9,538	.912	916	2.46	30	22306
15	Patrick Lalime P. Lalime	382	362	175	149	30	14	9,609	8,683	.904	926	2.53	32	21964
16	Dwayne Roloson D. Roloson	374	349	141	160	29	25	10,448	9,537	.913	911	2.56	21	21368
17	Marc Denis M. Denis	344	316	111	177	27	3	9,908	8,938	.902	970	3.02	16	19250
18	Tommy Salo T. Salo	326	318	140	129	50		8,312	7,531	.906	781	2.44	23	19168
19	Kevin Weekes K. Weekes	326	302	105	150	31	6	8,758	7,921	.904	837	2.82	19	17819
20	Dominik Hasek D. Hasek	321	318	194	84	20	13	8,007	7,336	.916	671	2.13	39	18934
21	Manny Legace M. Legace	320	299	175	83	16	18	7,967	7,266	.912	701	2.37	23	17769
22	Jocelyn Thibault J. Thibault	319	304	127	137	32	7	8,426	7,606	.903	820	2.73	27	18006
23	Dan Cloutier D. Cloutier	317	296	129	129	29	4	7,807	7,005	.897	802	2.78	15	17281
24	Manny Fernandez M. Fernandez	316	302	142	120	23	11	8,591	7,842	.913	749	2.48	15	18143
25	Mike Dunham M. Dunham	309	295	112	143	32	5	8,526	7,736	.907	790	2.72	15	17396