Between the 2000-01 and 2010-11 seasons, the Detroit Red Wings had the most wins by a team, with 500 wins.

Interpreted as:

most NHL team regular-season wins 2000-01 to 2010-11

	TEAM	W	GP	L	T	OTL	PTS	PTS%	SOW	SOL	G	GA	DIFF	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Red Wings	500	820	204	40	76	1,116	.680	27	33	2,602	2,041	561	21.3	84.4	32.88	9.7	27.10	.908
2	Devils	456	820	265	43	56	1,011	.616	42	25	2,191	1,923	268	17.2	83.7	30.10	8.9	26.38	.911
3	Sharks	451	820	251	41	77	1,020	.622	27	31	2,386	2,048	338	19.1	83.7	29.89	9.7	27.74	.910
4	Canucks	444	820	270	41	65	994	.606	26	33	2,437	2,116	321	18.6	83.6	29.31	10.1	28.15	.908
5	Senators	437	820	276	36	71	981	.598	18	33	2,521	2,156	365	19.1	83.9	30.44	10.1	27.99	.906
6	Stars	434	820	268	49	69	986	.601	44	31	2,278	2,079	199	17.8	83.1	28.15	9.9	26.63	.905
7	Sabres	418	820	301	33	68	937	.571	36	30	2,379	2,187	192	17.5	84.7	29.67	9.8	29.25	.909
8	Avalanche	415	820	296	44	65	939	.573	37	23	2,388	2,235	153	18.7	82.0	29.15	10.0	28.69	.905
9	Flyers	411	820	281	49	79	950	.579	19	34	2,383	2,198	185	17.8	83.1	30.18	9.6	28.70	.907
10	Bruins	399	820	285	40	96	934	.570	33	40	2,271	2,203	68	17.0	83.1	30.60	9.1	29.73	.910
11	Predators	399	820	311	46	64	908	.554	35	26	2,164	2,147	17	15.8	83.8	28.12	9.4	29.55	.911
12	Capitals	391	820	309	39	81	902	.550	26	38	2,373	2,384	-11	19.2	81.2	29.38	9.8	30.33	.904
13	Canadiens	390	820	319	35	76	891	.543	30	29	2,229	2,242	-13	19.0	82.8	28.44	9.6	31.06	.912
14	Ducks	389	820	314	38	79	895	.546	31	37	2,158	2,164	-6	18.7	83.2	28.83	9.1	29.70	.911
15	Flames	388	820	312	47	73	896	.546	23	31	2,174	2,177	-3	16.3	82.3	28.51	9.3	28.08	.905
16	Maple Leafs	387	820	312	38	83	895	.546	25	35	2,362	2,401	-39	17.7	80.6	29.51	9.8	28.76	.898
17	Rangers	381	820	336	26	77	865	.527	46	31	2,224	2,262	-38	16.7	82.5	30.20	9.0	29.41	.906
18	Hurricanes	378	820	322	50	70	876	.534	22	25	2,242	2,349	-107	16.3	82.3	30.18	9.1	29.05	.901
19	Penguins	377	820	338	31	74	859	.524	42	27	2,343	2,489	-146	18.2	81.8	28.41	10.1	30.50	.900
20	Blues	373	820	316	42	89	877	.535	30	36	2,204	2,240	-36	17.0	83.5	28.37	9.5	27.01	.899
21	Wild	370	820	326	55	69	864	.527	31	33	2,051	2,079	-28	16.3	85.0	26.29	9.5	29.48	.914
22	Kings	366	820	334	46	74	852	.520	40	28	2,208	2,298	-90	17.3	81.3	28.58	9.4	27.97	.900
23	Coyotes	364	820	337	55	64	847	.516	36	26	2,138	2,337	-199	16.0	81.3	28.21	9.2	30.37	.906
24	Blackhawks	359	820	337	45	79	842	.513	32	35	2,233	2,331	-98	15.7	82.8	29.52	9.2	28.12	.899
25	Lightning	355	820	343	41	81	832	.507	31	30	2,214	2,438	-224	17.2	81.8	28.93	9.3	29.15	.898