Since 2021-22, the Colorado Avalanche have the most wins by a team, with 227 wins.

Interpreted as:

most NHL regular-season wins 2021-22 to 2025-26

	TEAM	W	GP	L	OTL	PTS	PTS%	SOW	SOL	G	GA	DIFF	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Avalanche	227	357	99	31	485	.679	16	13	1,272	1,001	271	23.7	80.2	32.89	10.8	29.44	.905
2	Hurricanes	222	355	102	31	475	.669	8	14	1,174	928	246	21.3	85.3	33.48	9.9	26.04	.900
3	Maple Leafs	215	356	105	36	466	.654	10	8	1,250	1,054	196	24.7	79.8	31.44	11.2	29.95	.901
4	Stars	214	357	103	40	468	.655	17	11	1,183	986	197	24.1	81.7	30.17	11.0	29.49	.906
5	Bruins	213	358	110	35	461	.644	12	9	1,133	978	155	20.7	82.2	30.85	10.3	29.55	.908
6	Panthers	212	355	117	26	450	.634	15	8	1,219	1,023	196	23.2	79.7	34.45	10.0	28.90	.900
7	Oilers	209	357	117	31	449	.629	7	9	1,257	1,078	179	27.8	78.6	32.94	10.7	29.43	.897
8	Rangers	208	358	117	33	449	.627	14	9	1,136	979	157	23.2	81.9	29.88	10.6	29.80	.908
9	Jets	207	356	124	25	439	.617	6	8	1,114	949	165	21.7	78.8	29.97	10.4	30.03	.911
10	Lightning	205	356	119	32	442	.621	10	11	1,233	1,036	197	25.1	81.7	29.96	11.6	29.57	.902
11	Golden Knights	202	355	110	43	447	.630	15	17	1,148	1,003	145	21.9	77.9	31.68	10.2	28.99	.903
12	Wild	198	357	119	40	436	.611	21	17	1,095	1,043	52	21.6	76.8	30.10	10.2	30.45	.904
13	Kings	196	356	112	48	440	.618	14	20	1,087	969	118	20.1	79.7	31.58	9.7	27.39	.901
14	Capitals	187	357	125	45	419	.587	13	18	1,126	1,056	70	20.6	80.3	29.17	10.8	29.18	.899
15	Blues	183	357	135	39	405	.567	14	12	1,126	1,115	11	21.3	77.4	28.38	11.1	30.59	.898
16	Flames	178	358	129	51	407	.568	11	15	1,092	1,042	50	19.8	81.1	32.72	9.3	28.70	.899
17	Canucks	177	357	135	45	399	.559	14	11	1,111	1,103	8	22.5	76.5	28.72	10.8	29.53	.895
18	Devils	175	357	152	30	380	.532	9	13	1,120	1,114	6	22.1	81.5	30.96	10.1	28.83	.892
19	Predators	174	356	150	32	380	.534	16	4	1,036	1,108	-72	20.9	80.2	29.99	9.7	30.92	.899
20	Penguins	172	354	131	51	395	.558	7	20	1,108	1,091	17	21.4	80.8	32.16	9.7	30.96	.900
21	Islanders	169	357	138	50	388	.543	7	22	1,023	1,041	-18	17.4	78.2	29.78	9.6	30.97	.906
22	Senators	167	356	159	30	364	.511	14	5	1,059	1,139	-80	21.3	77.8	30.79	9.7	30.34	.895
23	Red Wings	162	357	155	40	364	.510	14	9	1,063	1,217	-154	22.2	76.0	28.65	10.4	30.90	.890
24	Sabres	160	356	161	35	355	.499	14	9	1,113	1,210	-97	20.0	77.3	30.17	10.4	30.96	.890
25	Kraken	153	354	162	39	345	.487	8	15	1,027	1,106	-79	18.4	76.0	28.56	10.2	28.34	.890