The Montreal Canadiens have the most wins by a team when the goal differential has been 5 or above goals, with 429 wins.

Interpreted as:

most regular-season wins by 5+ goals

	TEAM	W	DIFF	GP	L	T	OTL	PTS	PTS%	SOW	SOL	G	GA	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Canadiens	429	2,593	429	0	0	0	858	1.000	0	0	3,179	586	39.2	88.5	36.38	20.0	25.91	.951
2	Bruins	337	2,006	337	0	0	0	674	1.000	0	0	2,420	414	40.1	90.8	35.94	19.9	25.72	.952
3	Maple Leafs	309	1,831	309	0	0	0	618	1.000	0	0	2,221	390	37.7	94.1	35.53	19.6	29.88	.963
4	Red Wings	294	1,743	294	0	0	0	588	1.000	0	0	2,098	355	35.2	90.8	35.32	20.1	25.47	.950
5	Rangers	287	1,638	287	0	0	0	574	1.000	0	0	1,998	360	36.6	89.7	35.09	19.8	27.81	.954
6	Blackhawks	260	1,487	260	0	0	0	520	1.000	0	0	1,818	331	34.2	88.7	34.01	20.4	28.76	.957
7	Flyers	204	1,197	204	0	0	0	408	1.000	0	0	1,446	249	36.7	90.6	36.13	19.6	26.89	.955
8	Sabres	195	1,124	195	0	0	0	390	1.000	0	0	1,401	277	35.9	91.6	34.92	20.6	26.74	.947
9	Penguins	192	1,102	192	0	0	0	384	1.000	0	0	1,385	283	40.1	90.7	35.57	20.3	29.07	.949
10	Flames	181	1,075	181	0	0	0	362	1.000	0	0	1,352	277	38.2	89.2	35.41	21.1	27.20	.944
11	Islanders	170	1,007	170	0	0	0	340	1.000	0	0	1,237	230	34.6	90.9	33.54	21.7	28.20	.952
12	Blues	170	953	170	0	0	0	340	1.000	0	0	1,184	231	38.8	89.7	33.01	21.1	27.20	.950
13	Kings	169	978	169	0	0	0	338	1.000	0	0	1,222	244	37.2	88.9	35.27	20.5	27.78	.948
14	Oilers	167	981	167	0	0	0	334	1.000	0	0	1,270	289	36.3	88.7	33.54	22.7	30.02	.942
15	Stars	151	863	151	0	0	0	302	1.000	0	0	1,065	202	40.3	91.8	34.51	20.4	27.95	.952
16	Avalanche	139	795	139	0	0	0	278	1.000	0	0	972	177	38.4	92.0	34.04	20.5	27.37	.953
17	Capitals	137	801	137	0	0	0	274	1.000	0	0	981	180	39.4	90.9	33.25	21.5	27.76	.953
18	Canucks	128	722	128	0	0	0	256	1.000	0	0	867	145	35.6	90.5	33.01	20.5	26.73	.958
19	Devils	105	580	105	0	0	0	210	1.000	0	0	698	118	36.7	90.1	34.08	19.5	25.64	.956
20	Hurricanes	85	488	85	0	0	0	170	1.000	0	0	607	119	39.7	89.6	33.59	21.3	27.16	.948
21	Coyotes	80	470	80	0	0	0	160	1.000	0	0	562	92	30.7	89.6	33.34	21.1	29.18	.961
22	Senators	71	401	71	0	0	0	142	1.000	0	0	475	74	32.0	94.3	32.99	20.3	27.30	.962
23	Sharks	68	379	68	0	0	0	136	1.000	0	0	439	60	33.9	91.8	32.57	19.8	27.60	.968
24	Lightning	65	361	65	0	0	0	130	1.000	0	0	420	59	41.1	92.9	31.74	20.4	26.92	.966
25	Panthers	57	311	57	0	0	0	114	1.000	0	0	372	61	35.8	90.4	33.82	19.3	30.07	.964