The New Jersey Devils had the highest goal differential by a team in 2000-01, with a differential of 100 goals.

	TEAM	DIFF	SEASON	GP	W	L	T	OTL	PTS	PTS%	G	GA	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Devils	100	2000-01	82	48	19	12	3	111	.677	295	195	22.9	84.7	31.59	11.4	24.68	.904
2	Avalanche	78	2000-01	82	52	16	10	4	118	.720	270	192	22.0	82.7	29.21	11.3	25.11	.907
3	Senators	69	2000-01	82	48	21	9	4	109	.665	274	205	18.6	86.4	30.20	11.1	27.26	.908
4	Stars	54	2000-01	82	48	24	8	2	106	.646	241	187	19.6	86.2	25.61	11.5	24.91	.908
5	Blues	54	2000-01	82	43	22	12	5	103	.628	249	195	18.7	85.3	30.41	10.0	23.57	.899
6	Red Wings	51	2000-01	82	49	20	9	4	111	.677	253	202	22.1	85.7	32.32	9.5	27.09	.909
7	Sabres	34	2000-01	82	46	30	5	1	98	.598	218	184	16.1	88.0	26.88	9.9	26.77	.916
8	Flyers	33	2000-01	82	43	25	11	3	100	.610	240	207	15.7	82.5	29.90	9.8	26.15	.903
9	Maple Leafs	25	2000-01	82	37	29	11	5	90	.549	232	207	16.1	85.0	27.76	10.2	27.37	.908
10	Penguins	25	2000-01	82	42	28	9	3	96	.585	281	256	20.3	80.7	29.20	11.7	29.23	.893
11	Sharks	25	2000-01	82	40	27	12	3	95	.579	217	192	14.0	86.2	27.65	9.6	26.45	.911
12	Kings	24	2000-01	82	38	28	13	3	92	.561	252	228	19.3	81.2	27.90	11.0	26.34	.894
13	Capitals	22	2000-01	82	41	27	10	4	96	.585	233	211	21.2	84.1	28.63	9.9	27.72	.907
14	Oilers	21	2000-01	82	39	28	12	3	93	.567	243	222	14.8	83.8	26.16	11.3	26.09	.896
15	Coyotes	2	2000-01	82	35	27	17	3	90	.549	214	212	16.6	85.2	25.06	10.4	29.63	.913
16	Canucks	1	2000-01	82	36	28	11	7	90	.549	239	238	17.1	80.9	29.68	9.8	25.88	.888
17	Hurricanes	-13	2000-01	82	38	32	9	3	88	.537	212	225	18.8	87.2	27.04	9.6	26.90	.898
18	Predators	-14	2000-01	82	34	36	9	3	80	.488	186	200	14.1	85.2	26.61	8.5	28.62	.915
19	Bruins	-22	2000-01	82	36	30	8	8	88	.537	227	249	16.4	82.8	28.77	9.6	26.72	.886
20	Canadiens	-26	2000-01	82	28	40	8	6	70	.427	206	232	16.2	82.2	26.20	9.6	28.01	.899
21	Blackhawks	-36	2000-01	82	29	40	8	5	71	.433	210	246	12.9	83.9	26.34	9.7	26.71	.888
22	Flames	-39	2000-01	82	27	36	15	4	73	.445	197	236	14.9	79.9	27.20	8.8	27.12	.894
23	Rangers	-40	2000-01	82	33	43	5	1	72	.439	250	290	17.9	78.5	28.60	10.7	31.40	.887
24	Wild	-42	2000-01	82	25	39	13	5	68	.415	168	210	9.6	84.7	24.63	8.3	28.13	.909
25	Blue Jackets	-43	2000-01	82	28	39	9	6	71	.433	190	233	14.7	80.7	25.39	9.1	30.18	.906