Between the 2006-07 and 2018-19 seasons, the Pittsburgh Penguins had the most wins by a team, with 605 wins.

Interpreted as:

NHL most regular-season wins 2006-07 to 2018-19

	TEAM	W	GP	L	OTL	PTS	PTS%	SOW	SOL	G	GA	DIFF	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Penguins	605	1,032	322	105	1,315	.637	76	47	3,196	2,775	421	20.4	83.0	31.56	9.8	30.08	.911
2	Sharks	594	1,032	325	113	1,301	.630	68	56	3,013	2,627	386	21.1	82.4	32.00	9.1	28.17	.910
3	Capitals	583	1,032	328	121	1,287	.624	54	60	3,137	2,798	339	21.5	81.3	30.22	10.1	30.31	.911
4	Bruins	571	1,032	339	122	1,264	.612	62	65	2,972	2,607	365	19.7	82.8	31.57	9.1	30.08	.916
5	Ducks	563	1,032	344	125	1,251	.606	61	68	2,845	2,698	147	19.6	82.4	29.49	9.3	30.03	.913
6	Blackhawks	554	1,032	355	123	1,231	.596	67	58	3,043	2,804	239	17.8	80.8	31.64	9.3	29.52	.908
7	Predators	554	1,032	354	124	1,232	.597	60	64	2,870	2,692	178	17.3	82.2	29.86	9.3	29.74	.912
8	Blues	551	1,032	366	115	1,217	.590	66	55	2,818	2,662	156	18.1	83.6	29.46	9.3	28.10	.908
9	Rangers	544	1,032	378	110	1,198	.580	70	60	2,826	2,650	176	17.6	83.2	30.55	9.0	29.88	.914
10	Red Wings	536	1,032	352	144	1,216	.589	62	68	2,925	2,785	140	19.5	81.5	31.66	9.0	28.81	.906
11	Lightning	535	1,032	389	108	1,178	.571	59	52	3,058	2,998	60	19.7	80.9	29.71	10.0	30.03	.903
12	Wild	528	1,032	388	116	1,172	.568	63	63	2,722	2,668	54	18.7	83.1	28.61	9.2	29.65	.913
13	Canadiens	527	1,032	385	120	1,174	.569	62	59	2,829	2,779	50	19.2	82.7	30.17	9.1	30.83	.913
14	Stars	524	1,032	393	115	1,163	.563	57	52	2,877	2,867	10	18.0	81.1	29.64	9.4	29.45	.906
15	Canucks	524	1,032	391	117	1,165	.564	61	68	2,784	2,743	41	18.4	82.9	29.60	9.1	30.28	.912
16	Flames	515	1,032	407	110	1,140	.552	43	56	2,896	2,891	5	17.8	81.3	29.32	9.6	29.31	.904
17	Devils	507	1,032	404	121	1,135	.550	65	69	2,552	2,671	-119	18.0	83.1	28.50	8.7	28.50	.909
18	Kings	501	1,032	410	121	1,123	.544	61	66	2,684	2,676	8	18.3	81.9	30.21	8.6	28.31	.908
19	Flyers	500	1,032	394	138	1,138	.551	41	77	2,956	2,965	-9	19.7	81.9	30.65	9.3	30.45	.906
20	Jets	496	1,032	420	116	1,108	.537	65	50	2,934	3,066	-132	18.0	79.6	29.79	9.5	31.43	.905
21	Senators	488	1,032	421	123	1,099	.532	53	67	2,880	3,005	-125	17.7	81.6	30.50	9.2	31.57	.908
22	Blue Jackets	488	1,032	434	110	1,086	.526	60	62	2,748	2,908	-160	16.3	81.2	29.73	9.0	30.13	.906
23	Avalanche	483	1,032	449	100	1,066	.516	69	34	2,796	3,034	-238	18.0	80.3	29.51	9.2	31.16	.906
24	Hurricanes	474	1,032	425	133	1,081	.524	33	57	2,787	2,966	-179	17.0	81.4	31.49	8.6	29.73	.903
25	Islanders	473	1,032	430	129	1,075	.521	70	61	2,808	3,070	-262	17.5	80.1	30.23	9.0	31.32	.905