Between the 1999-00 and 2009-10 seasons, the Detroit Red Wings had the most wins by a team, with 501 wins.

Interpreted as:

NHL most regular-season wins since 1999-00 to 2009-10

	TEAM	W	GP	L	T	OTL	PTS	PTS%	SOW	SOL	G	GA	DIFF	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Red Wings	501	820	201	50	68	1,120	.683	23	29	2,623	2,014	609	21.1	84.7	32.71	9.8	26.68	.908
2	Devils	463	820	250	51	56	1,033	.630	39	23	2,271	1,919	352	17.7	84.1	30.55	9.1	26.32	.911
3	Senators	446	820	264	47	63	1,002	.611	16	28	2,575	2,121	454	19.0	84.2	30.69	10.2	27.38	.906
4	Sharks	438	820	256	51	75	1,002	.611	22	26	2,368	2,054	314	18.5	84.0	29.18	9.9	27.73	.910
5	Stars	435	820	262	59	64	993	.605	39	24	2,267	2,037	230	17.6	83.9	27.94	9.9	26.24	.905
6	Avalanche	427	820	280	55	58	967	.590	31	22	2,400	2,149	251	18.8	82.7	28.90	10.1	28.30	.907
7	Canucks	420	820	280	56	64	960	.585	22	28	2,406	2,173	233	17.9	83.1	28.78	10.2	27.93	.905
8	Sabres	410	820	304	44	62	926	.565	31	29	2,352	2,163	189	16.7	84.9	29.11	9.9	28.88	.909
9	Flyers	409	820	280	61	70	949	.579	16	27	2,364	2,161	203	18.2	83.5	30.05	9.6	28.05	.906
10	Maple Leafs	395	820	305	45	75	910	.555	20	29	2,395	2,378	17	17.9	81.0	29.27	10.0	28.57	.898
11	Capitals	387	820	310	51	72	897	.547	21	32	2,381	2,387	-6	19.0	81.3	29.02	10.0	30.20	.904
12	Blues	386	820	302	53	79	904	.551	26	30	2,216	2,177	39	17.0	84.0	28.34	9.5	26.45	.900
13	Predators	383	820	324	53	60	879	.536	29	22	2,150	2,197	-47	15.7	83.8	27.94	9.4	29.53	.909
14	Canadiens	381	820	323	44	72	878	.535	27	26	2,212	2,230	-18	18.7	83.0	27.87	9.7	30.73	.911
15	Flames	378	820	319	57	66	879	.536	14	24	2,144	2,203	-59	16.2	82.1	28.47	9.2	28.13	.905
16	Bruins	377	820	293	59	91	904	.551	31	34	2,237	2,262	-25	16.8	82.9	30.38	9.0	29.24	.906
17	Ducks	376	820	317	50	77	879	.536	27	35	2,140	2,158	-18	18.1	83.0	28.86	9.0	29.22	.910
18	Hurricanes	375	820	326	60	59	869	.530	17	20	2,228	2,331	-103	16.4	82.5	29.75	9.1	28.34	.900
19	Rangers	366	820	341	38	75	845	.515	37	28	2,218	2,313	-95	16.7	82.5	30.16	9.0	29.46	.904
20	Penguins	365	820	344	39	72	841	.513	32	24	2,356	2,529	-173	18.2	81.5	27.87	10.3	30.50	.899
21	Oilers	360	820	325	63	72	855	.521	39	26	2,221	2,310	-89	15.7	82.9	27.75	9.8	28.65	.902
22	Coyotes	360	820	342	63	55	838	.511	31	20	2,144	2,345	-201	15.6	81.9	27.87	9.4	29.95	.905
23	Kings	359	820	331	58	72	848	.517	30	26	2,244	2,330	-86	17.4	81.1	28.65	9.6	27.98	.898
24	Blackhawks	348	820	345	55	72	823	.502	26	30	2,223	2,356	-133	15.1	83.2	28.87	9.4	28.17	.898
25	Wild	331	738	291	55	61	778	.527	28	28	1,848	1,851	-3	16.2	85.3	26.30	9.5	29.19	.914