Tage Thompson recorded the most goals for the Sabres in 2021-22, with 38 scored.

	NAME	G	SEASON	TM	GP	A	P	+/-	PIM	PPG	PPA	SHG	SHA	GWG	OTG	S	S%	FOW	FO	FOW%	HIT	BKS	TKA	GVA	TOI/GP
1	Tage Thompson T. Thompson	38	2021-22	BUF	78	30	68	-17	37	10	6	2	0	4	1	253	15.0	393	975	40.3	66	25	49	42	17:53
2	Jeff Skinner J. Skinner	33	2021-22	BUF	80	30	63	-14	42	5	6	0	0	4	0	262	12.6	91	224	40.6	29	20	51	52	17:06
3	Kyle Okposo K. Okposo	21	2021-22	BUF	74	24	45	-15	43	8	6	2	0	1	0	174	12.1	92	185	49.7	59	19	24	34	16:47
4	Victor Olofsson V. Olofsson	20	2021-22	BUF	72	29	49	-16	6	7	5	0	1	6	0	164	12.2	0	1	0.0	10	15	18	18	15:23
5	Vinnie Hinostroza V. Hinostroza	13	2021-22	BUF	62	12	25	-11	24	1	0	0	0	2	0	92	14.1	12	28	42.9	25	13	22	26	13:52
6	Rasmus Dahlin R. Dahlin	13	2021-22	BUF	80	40	53	-22	68	3	18	0	1	3	1	170	7.6	0	0		121	91	27	51	24:01
7	Dylan Cozens D. Cozens	13	2021-22	BUF	79	25	38	-19	55	2	7	0	1	1	0	160	8.1	383	840	45.6	35	22	33	30	15:54
8	Alex Tuch A. Tuch	12	2021-22	BUF	50	26	38	-3	14	2	6	1	0	0	0	139	8.6	9	23	39.1	32	49	40	25	18:25
9	Zemgus Girgensons Z. Girgensons	10	2021-22	BUF	56	8	18	-7	27	3	1	0	0	1	0	92	10.9	143	287	49.8	81	25	24	10	14:47
10	Rasmus Asplund R. Asplund	8	2021-22	BUF	80	19	27	-5	10	2	2	1	0	1	1	130	6.2	26	61	42.6	30	14	21	23	14:17
11	Peyton Krebs P. Krebs	7	2021-22	BUF	48	15	22	-20	20	0	10	0	0	2	0	46	15.2	58	165	35.2	19	5	13	31	14:45
12	Casey Mittelstadt C. Mittelstadt	6	2021-22	BUF	40	13	19	-14	4	1	6	0	0	1	1	79	7.6	202	452	44.7	19	12	13	17	16:07
13	Anders Bjork A. Bjork	5	2021-22	BUF	58	3	8	-14	10	0	0	0	0	0	0	51	9.8	1	5	20.0	11	16	16	11	12:02
14	Cody Eakin C. Eakin	4	2021-22	BUF	69	8	12	-15	22	1	1	0	1	1	0	74	5.4	482	860	56.0	33	29	22	20	13:35
15	Mark Pysyk M. Pysyk	3	2021-22	BUF	68	9	12	-4	16	0	0	0	0	0	0	64	4.7	0	0		41	85	21	20	17:49
16	Henri Jokiharju H. Jokiharju	3	2021-22	BUF	60	16	19	-8	20	0	4	0	0	0	0	83	3.6	0	0		73	60	12	36	21:53
17	Drake Caggiula D. Caggiula	2	2021-22	BUF	18	3	5	-4	4	0	1	0	0	1	0	23	8.7	1	4	25.0	17	7	6	2	14:38
18	Colin Miller C. Miller	2	2021-22	BUF	38	12	14	-2	21	0	3	0	0	0	0	48	4.2	0	0		50	42	6	13	18:59
19	Will Butcher W. Butcher	2	2021-22	BUF	37	6	8	-10	0	0	2	0	0	0	0	35	5.7	0	0		11	32	1	10	16:29
20	John Hayden J. Hayden	2	2021-22	BUF	55	2	4	-12	84	0	0	0	0	0	0	65	3.1	2	9	22.2	104	24	12	10	10:51
21	Mark Jankowski M. Jankowski	2	2021-22	BUF	19	3	5	+2	4	0	0	0	0	1	0	14	14.3	86	179	48.0	5	8	4	10	13:39
22	Brett Murray B. Murray	2	2021-22	BUF	19	4	6	-3	23	0	1	0	0	0	0	14	14.3	0	0		17	2	4	5	12:59
23	Arttu Ruotsalainen A. Ruotsalainen	2	2021-22	BUF	18	2	4	-1	6	0	0	0	0	0	0	23	8.7	51	120	42.5	14	6	5	0	11:53
24	Owen Power O. Power	2	2021-22	BUF	8	1	3	+3	2	0	0	0	0	0	0	10	20.0	0	0		1	9	6	4	22:05
25	Robert Hagg R. Hagg	1	2021-22	BUF	48	7	8	-9	25	0	0	0	0	0	0	45	2.2	0	0		97	91	6	17	17:01