The Michigan State Spartans had their most passing yards in a game against Northwestern on October 28, 2017, with 445 yards.

Interpreted as:

michigan state most passing yards in a game

	TEAM	YDS	DATE	TM		OPP	RESULT	CMP	ATT	PCT	AVG	TD	INT	RTG	TD%	INT%	SCK	SCKY
1	Michigan State	445	10/28/2017	MSU	@	NW	L 31-39	39	57	68.4	7.8	4	1	153.6	7.0	1.8	1	10
2	Michigan State	424	10/15/2016	MSU	vs	NW	L 40-54	27	42	64.3	10.1	4	1	175.8	9.5	2.4	4	34
3	Michigan State	400	11/4/2017	MSU	vs	PSU	W 27-24	33	56	58.9	7.1	2	1	127.1	3.6	1.8	2	10
4	Michigan State	400	10/9/1999	MSU	vs	MICH	W 34-31	21	36	58.3	11.1	2	0	170.0	5.6	0.0
5	Michigan State	398	10/24/2015	MSU	vs	IND	W 52-26	30	52	57.7	7.7	4	0	147.4	7.7	0.0	4	22
6	Michigan State	396	11/14/1998	MSU	vs	PUR	L 24-25	32	48	66.7	8.3	3	1	152.4	6.3	2.1
7	Michigan State	382	10/4/2003	MSU	vs	IND	W 31-3	33	41	80.5	9.3	2	0	174.8	4.9	0.0
8	Michigan State	375	12/1/2001	MSU	vs	MIZ	W 55-7	17	27	63.0	13.9	3	1	208.9	11.1	3.7
9	Michigan State	373	11/8/2003	MSU	@	OSU	L 23-33	36	56	64.3	6.7	2	2	124.9	3.6	3.6
10	Michigan State	367	10/10/2015	MSU	@	RUTG	W 31-24	24	39	61.5	9.4	2	1	152.4	5.1	2.6	1	6
11	Michigan State	363	9/7/2024	MSU	@	MD	W 27-24	24	38	63.2	9.6	3	2	158.9	7.9	5.3	3	18
12	Michigan State	358	11/8/2014	MSU	vs	OSU	L 37-49	25	45	55.6	8.0	2	0	137.0	4.4	0.0	2	3
13	Michigan State	357	11/22/2003	MSU	vs	PSU	W 41-10	29	50	58.0	7.1	4	1	140.4	8.0	2.0
14	Michigan State	356	11/24/2001	MSU	vs	PSU	L 37-42	24	36	66.7	9.9	3	0	177.2	8.3	0.0
15	Michigan State	354	12/30/2021	MSU	vs	PITT	W 31-21	29	50	58.0	7.1	3	1	133.3	6.0	2.0	3	24
16	Michigan State	354	8/29/2014	MSU	vs	JVST	W 45-7	18	24	75.0	14.8	3	0	240.2	12.5	0.0	0	0
17	Michigan State	351	9/6/2003	MSU	vs	RUTG	W 44-28	21	34	61.8	10.3	3	2	165.8	8.8	5.9
18	Michigan State	351	10/20/2001	MSU	@	MINN	L 19-28	27	47	57.4	7.5	2	1	130.0	4.3	2.1
19	Michigan State	348	11/7/2015	MSU	@	NEB	L 38-39	24	39	61.5	8.9	4	1	165.2	10.3	2.6	0	0
20	Michigan State	345	9/23/2017	MSU	vs	ND	L 18-38	32	53	60.4	6.5	2	1	123.7	3.8	1.9	2	12
21	Michigan State	343	9/6/2014	MSU	@	ORE	L 27-46	29	47	61.7	7.3	2	2	128.5	4.3	4.3	3	11
22	Michigan State	342	11/30/2019	MSU	vs	MD	W 19-16	30	42	71.4	8.1	0	2	130.3	0.0	4.8	0	0
23	Michigan State	340	10/15/2005	MSU	@	OSU	L 24-35	26	36	72.2	9.4	1	0	160.7	2.8	0.0	12
24	Michigan State	339	10/9/2021	MSU	@	RUTG	W 31-13	16	27	59.3	12.6	3	1	194.0	11.1	3.7	0	0
25	Michigan State	332	10/18/2014	MSU	@	IND	W 56-17	24	32	75.0	10.4	3	1	186.8	9.4	3.1	1	4