Since 2000, Michael Turner has the most rush attempts in a game, with 52 carries against Central Michigan on November 18, 2000.

most carries by a player in a college football game since 2000

	NAME	ATT	DATE	TM		OPP	RUSH YDS	YPC	RUSH TD	REC YDS	REC	TRG	AVG	REC TD
1	Michael Turner M. Turner	52	11/18/2000	NIU	vs	CMU	281	5.4	1
2	D'Onta Foreman D. Foreman	51	11/19/2016	TEX	@	KU	250	4.9	2	-1	1	1	-1.0	0
3	Chris Perry C. Perry	51	11/1/2003	MICH	@	MSU	219	4.3	1	17	2		8.5	0
4	LaDainian Tomlinson L. Tomlinson	49	10/7/2000	TCU	vs	HAW	294	6.0	4	6	1		6.0	0
5	Ka'Deem Carey K. Carey	48	11/23/2013	ARIZ	vs	ORE	206	4.3	4	-5	1	1	-5.0	0
6	Tanardo Sharps T. Sharps	48	11/16/2002	TEM	@	RUTG	215	4.5	1	7	1		7.0	0
7	Michael Bennett M. Bennett	48	9/23/2000	WIS	vs	NW	293	6.1	2	27	3		9.0	0
8	Dion Lewis D. Lewis	47	12/5/2009	PITT	vs	CIN	194	4.1	3	34	5		6.8	0
9	Larry Ned L. Ned	47	11/17/2001	SDSU	vs	WYO	209	4.4	4
10	D'Angelo Brewer D. Brewer	46	9/24/2016	TLSA	@	FRES	252	5.5	0	-1	1	1	-1.0	0
11	Derrick Henry D. Henry	46	11/28/2015	ALA	@	AUB	271	5.9	1
12	Tre Mason T. Mason	46	12/7/2013	AUB	vs	MIZ	304	6.6	4	8	1	1	8.0	0
13	Kevin Smith K. Smith	46	11/24/2007	UCF	vs	UTEP	219	4.8	1	30	3		10.0	0
14	Laurence Maroney L. Maroney	46	9/24/2005	MINN	vs	PUR	217	4.7	0	59	5		11.8	0
15	Dewhitt Betterson D. Betterson	46	11/15/2003	TROY	@	USU	230	5.0	2
16	Keylon Kincade K. Kincade	46	10/19/2002	SMU	vs	LT	158	3.4	2	31	2		15.5	0
17	Anthony Jones A. Jones	46	10/7/2000	BALL	@	M-OH	187	4.1	1	38	3		12.7	1
18	Tyler Gaffney T. Gaffney	45	11/7/2013	STAN	vs	ORE	157	3.5	1	15	1	1	15.0	0
19	Bobby Rainey B. Rainey	45	11/20/2010	WKU	vs	MTSU	248	5.5	2	34	4		8.5	0
20	Anthony Davis A. Davis	45	11/23/2002	WIS	vs	MINN	301	6.7	5
21	Chance Kretschmer C. Kretschmer	45	11/24/2001	NEV	@	UTEP	327	7.3	6
22	Hodges Mitchell H. Mitchell	45	11/4/2000	TEX	@	TTU	229	5.1	2	38	6		6.3	0
23	Lew Nichols L. Nichols	44	11/26/2021	CMU	vs	EMU	194	4.4	1	39	2	2	19.5	0
24	Isaiah Sanders I. Sanders	44	11/25/2017	AFA	vs	USU	196	4.5	3
25	TaQuon Marshall T. Marshall	44	9/4/2017	GT	vs	TENN	249	5.7	5	0	0	0		0