Barry Sanders has the most rushing yards by a running back in a season, with 2,628 yards in 1988.

	NAME	RUSH YDS	SEASON	TM	GP	ATT	YPC	RUSH YDS/G	RUSH TD	REC YDS	REC	TRG	AVG	REC YDS/G	REC TD
1	Barry Sanders B. Sanders	2,628	1988	OKST	11	344	7.6	238.9	37	106	19		5.6	9.6	0
2	Ashton Jeanty A. Jeanty	2,601	2024	BSU	14	374	7.0	185.8	29	138	23	35	6.0	9.9	1
3	Melvin Gordon M. Gordon	2,587	2014	WIS	14	343	7.5	184.8	29	153	19	27	8.1	10.9	3
4	Kevin Smith K. Smith	2,567	2007	UCF	14	450	5.7	183.4	29	242	24		10.1	17.3	1
5	Marcus Allen M. Allen	2,342	1981	USC	11	403	5.8	212.9	22	217	29		7.5	19.7	1
6	Rashaad Penny R. Penny	2,248	2017	SDSU	13	289	7.8	172.9	23	135	19	27	7.1	10.4	2
7	Derrick Henry D. Henry	2,219	2015	ALA	15	395	5.6	147.9	28	91	11	17	8.3	6.1	0
8	Jonathan Taylor J. Taylor	2,194	2018	WIS	13	307	7.1	168.8	16	60	8	14	7.5	4.6	0
9	Troy Davis T. Davis	2,185	1996	ISU	11	402	5.4	198.6	21	64	13		4.9	5.8	0
10	Andre Williams A. Williams	2,177	2013	BC	13	355	6.1	167.5	18	0	0	1		0.0	0
11	LaDainian Tomlinson L. Tomlinson	2,158	2000	TCU	11	369	5.8	196.2	22	40	10		4.0	3.6	0
12	Donnel Pumphrey D. Pumphrey	2,133	2016	SDSU	14	349	6.1	152.4	17	231	27	39	8.6	16.5	0
13	Matt Forte M. Forte	2,127	2007	TULN	12	361	5.9	177.3	23	282	32		8.8	23.5	0
14	Ricky Williams R. Williams	2,124	1998	TEX	11	361	5.9	193.1	27	262	24		10.9	23.8	1
15	Darrell Henderson D. Henderson	2,119	2018	MEM	14	230	9.2	151.4	25	304	21	27	14.5	21.7	3
16	Bryce Love B. Love	2,118	2017	STAN	13	263	8.1	162.9	19	33	6	8	5.5	2.5	0
17	Chuba Hubbard C. Hubbard	2,094	2019	OKST	13	328	6.4	161.1	21	198	23	30	8.6	15.2	0
18	Larry Johnson L. Johnson	2,087	2002	PSU	13	271	7.7	160.5	20	349	41		8.5	26.8	3
19	Donald Brown D. Brown	2,083	2008	CONN	13	367	5.7	160.2	18	125	21		6.0	9.6	0
20	Rashaan Salaam R. Salaam	2,055	1994	COLO	11	298	6.9	186.8	24	294	24		12.3	26.7	0
21	Tevin Coleman T. Coleman	2,036	2014	IND	12	270	7.5	169.7	15	141	25	33	5.6	11.8	0
22	D'Onta Foreman D. Foreman	2,028	2016	TEX	11	323	6.3	184.4	15	75	7	9	10.7	6.8	0
23	Christian McCaffrey C. McCaffrey	2,019	2015	STAN	14	337	6.0	144.2	8	645	45	54	14.3	46.1	5
24	J.J. Arrington	2,018	2004	CAL	12	289	7.0	168.2	15	121	21		5.8	10.1	0
25	Ray Rice R. Rice	2,012	2007	RUTG	13	380	5.3	154.8	24	239	25		9.6	18.4	1