The Notre Dame Fighting Irish have a record of 13-12 against USC since 2000.

	TEAM	DATE	REC	TM		OPP	RESULT	W%	TD	1DWN	OFF	OPP OFF	3DWN%	4DWN%
1	Notre Dame	11/25/2000	1-0	ND	@	USC	W 38-21	1.000	5	22	388	329
2	Notre Dame	10/20/2001	1-0	ND	vs	USC	W 27-16	1.000	3	19	346	290
3	Notre Dame	11/30/2002	0-1	ND	@	USC	L 13-44	.000	1	4	109	610
4	Notre Dame	10/18/2003	0-1	ND	vs	USC	L 14-45	.000	2	16	279	551
5	Notre Dame	11/27/2004	0-1	ND	@	USC	L 10-41	.000	1	16	300	488
6	Notre Dame	10/15/2005	0-1	ND	vs	USC	L 31-34	.000	4	28	417	476
7	Notre Dame	11/25/2006	0-1	ND	@	USC	L 24-44	.000	3
8	Notre Dame	10/20/2007	0-1	ND	vs	USC	L 0-38	.000	0
9	Notre Dame	11/29/2008	0-1	ND	@	USC	L 3-38	.000	0
10	Notre Dame	10/17/2009	0-1	ND	vs	USC	L 27-34	.000	4
11	Notre Dame	11/27/2010	1-0	ND	@	USC	W 20-16	1.000	3
12	Notre Dame	10/22/2011	0-1	ND	vs	USC	L 17-31	.000	2
13	Notre Dame	11/24/2012	1-0	ND	@	USC	W 22-13	1.000	1
14	Notre Dame	10/19/2013	1-0	ND	vs	USC	W 14-10	1.000	2	17	295	330	28.6	0.0
15	Notre Dame	11/29/2014	0-1	ND	@	USC	L 14-49	.000	2	20	349	577	42.9	0.0
16	Notre Dame	10/17/2015	1-0	ND	vs	USC	W 41-31	1.000	5	21	476	590	41.7
17	Notre Dame	11/26/2016	0-1	ND	@	USC	L 27-45	.000	4	23	408	412	29.4	100.0
18	Notre Dame	10/21/2017	1-0	ND	vs	USC	W 49-14	1.000	7	23	497	336	53.8
19	Notre Dame	11/24/2018	1-0	ND	@	USC	W 24-17	1.000	3	23	473	443	40.0	50.0
20	Notre Dame	10/12/2019	1-0	ND	vs	USC	W 30-27	1.000	3	25	473	426	52.9	0.0
21	Notre Dame	10/23/2021	1-0	ND	vs	USC	W 31-16	1.000	4	26	383	424	66.7	100.0
22	Notre Dame	11/26/2022	0-1	ND	@	USC	L 27-38	.000	4	22	408	436	71.4	0.0
23	Notre Dame	10/14/2023	1-0	ND	vs	USC	W 48-20	1.000	6	13	251	308	30.0
24	Notre Dame	11/30/2024	1-0	ND	@	USC	W 49-35	1.000	7	23	436	557	33.3	100.0
25	Notre Dame	10/18/2025	1-0	ND	vs	USC	W 34-24	1.000	5	23	442	396	27.3	50.0
	Average							.520	3.2		373.9	443.3
	Total		13-12					.520	81		6,730	7,979