Chris Weinke had the most passing yards in 2000, with 4,167 yards.

	NAME	YDS	SEASON	TM	GP	CMP	ATT	PCT	AVG	YDS/G	TD	INT	RTG	TD%	INT%
1	Chris Weinke C. Weinke	4,167	2000	FSU	12	266	431	61.7	9.7	347.3	33	11	163.1	7.7	2.6
2	Jared Lorenzen J. Lorenzen	3,687	2000	UK	11	321	559	57.4	6.6	335.2	19	21	116.5	3.4	3.8
3	Kliff Kingsbury K. Kingsbury	3,412	2000	TTU	12	361	584	61.8	5.8	284.3	21	17	116.9	3.6	2.9
4	Drew Brees D. Brees	3,393	2000	PUR	11	286	473	60.5	7.2	308.5	24	12	132.4	5.1	2.5
5	Josh Heupel J. Heupel	3,392	2000	OKLA	12	280	433	64.7	7.8	282.7	20	14	139.2	4.6	3.2
6	Bart Hendricks B. Hendricks	3,364	2000	BSU	11	210	347	60.5	9.7	305.8	35	8	170.6	10.1	2.3
7	Byron Leftwich B. Leftwich	3,358	2000	MRSH	12	279	457	61.1	7.3	279.8	21	9	134.0	4.6	2.0
8	John Welsh J. Welsh	3,171	2000	IDHO	11	251	399	62.9	7.9	288.3	22	17	139.3	5.5	4.3
9	Philip Rivers P. Rivers	3,054	2000	NCST	11	237	441	53.7	6.9	277.6	25	10	126.1	5.7	2.3
10	Timmy Chang T. Chang	3,041	2000	HAW	10	245	469	52.2	6.5	304.1	19	19	112.0	4.1	4.1
11	Carson Palmer C. Palmer	2,914	2000	USC	12	228	415	54.9	7.0	242.8	16	18	118.0	3.9	4.3
12	George Godsey G. Godsey	2,906	2000	GT	11	222	349	63.6	8.3	264.2	23	6	151.9	6.6	1.7
13	Patrick Ramsey P. Ramsey	2,833	2000	TULN	10	229	389	58.9	7.3	283.3	24	14	133.2	6.2	3.6
14	Ken Dorsey K. Dorsey	2,737	2000	MIA	11	188	322	58.4	8.5	248.8	25	5	152.3	7.8	1.6
15	Jose Fuentes J. Fuentes	2,709	2000	USU	10	194	368	52.7	7.4	270.9	16	8	124.6	4.3	2.2
16	Jason McKinley J. McKinley	2,696	2000	HOU	11	251	428	58.6	6.3	245.1	14	13	116.3	3.3	3.0
17	Joey Harrington J. Harrington	2,694	2000	ORE	11	195	375	52.0	7.2	244.9	20	13	123.0	5.3	3.5
18	Rocky Perez R. Perez	2,661	2000	UTEP	11	200	338	59.2	7.9	241.9	26	6	147.1	7.7	1.8
19	Jonathan Beasley J. Beasley	2,636	2000	KSU	13	156	313	49.8	8.4	202.8	17	10	132.1	5.4	3.2
20	Dave Ragone D. Ragone	2,621	2000	LOU	11	216	354	61.0	7.4	238.3	27	11	142.2	7.6	3.1
21	Matt Newton M. Newton	2,609	2000	CSU	11	198	336	58.9	7.8	237.2	21	13	137.0	6.3	3.9
22	Mark Farris M. Farris	2,551	2000	TAMU	11	208	347	59.9	7.4	231.9	10	9	126.0	2.9	2.6
23	Luke McCown L. McCown	2,544	2000	LT	8	244	369	66.1	6.9	318.0	21	15	134.7	5.7	4.1
24	Jeff Welsh J. Welsh	2,537	2000	WMU	12	207	354	58.5	7.2	211.4	15	12	125.9	4.2	3.4
25	Josh Blankenship J. Blankenship	2,507	2000	TLSA	12	196	379	51.7	6.6	208.9	9	11	109.3	2.4	2.9