Donnel Pumphrey has the most career rushing yards, with 6,405 yards.

	NAME	RUSH YDS	GP	ATT	YPC	RUSH YDS/G	RUSH TD	REC YDS	REC	TRG	AVG	REC YDS/G	REC TD
1	Donnel Pumphrey D. Pumphrey	6,405	54	1,059	6.0	118.6	62	1,041	100	124	10.4	19.3	5
2	Ron Dayne R. Dayne	6,397	43	1,115	5.7	148.8	63	304	31		9.8	7.1	0
3	Ricky Williams R. Williams	6,279	46	1,011	6.2	136.5	72	927	85		10.9	20.2	3
4	Jonathan Taylor J. Taylor	6,174	41	926	6.7	150.6	50	407	42	67	9.7	9.9	5
5	Tony Dorsett T. Dorsett	6,082	44	1,074	5.7	138.2	55	404	38		10.6	9.2	4
6	DeAngelo Williams D. Williams	6,026	44	969	6.2	137.0	55	723	70		10.3	16.4	5
7	Royce Freeman R. Freeman	5,621	51	947	5.9	110.2	60	814	79	91	10.3	16.0	4
8	Charles White C. White	5,598	45	1,023	5.5	124.4	46	507	54		9.4	11.3	3
9	Travis Prentice T. Prentice	5,596	44	1,138	4.9	127.2	73	522	54		9.7	11.9	5
10	Cedric Benson C. Benson	5,540	48	1,112	5.0	115.4	64	621	69		9.0	12.9	3
11	Justin Jackson J. Jackson	5,440	51	1,142	4.8	106.7	41	858	122	165	7.0	16.8	1
12	Garrett Wolfe G. Wolfe	5,434	34	849	6.4	159.8	54	588	58		10.1	17.3	5
13	Myles Gaskin M. Gaskin	5,323	52	945	5.6	102.4	57	465	65	91	7.2	8.9	5
14	Damion Fletcher D. Fletcher	5,302	50	1,009	5.3	106.0	44	904	109		8.3	18.1	2
15	LaDainian Tomlinson L. Tomlinson	5,263	44	907	5.8	119.6	54	238	39		6.1	5.4	0
16	Herschel Walker H. Walker	5,259	33	994	5.3	159.4	49	243	26		9.3	7.4	3
17	Archie Griffin A. Griffin	5,177	42	845	6.1	123.3	25	286	25		11.4	6.8	1
18	Montee Ball M. Ball	5,140	49	924	5.6	104.9	77	598	59		10.1	12.2	6
19	Marquez Cooper M. Cooper	5,135	54	1,101	4.7	95.1	45	496	57	79	8.7	9.2	2
20	LaMichael James L. James	5,082	37	771	6.6	137.4	53	586	51		11.5	15.8	4
21	Michael Hart M. Hart	5,040	43	1,015	5.0	117.2	41	566	67		8.4	13.2	2
22	Avon Cobourne A. Cobourne	5,039	43	1,023	4.9	117.2	42	459	57		8.1	10.7	0
23	Darren Lewis D. Lewis	5,012	46	909	5.5	109.0	44	126	25		5.0	2.7	1
24	Darren Sproles D. Sproles	4,979	45	815	6.1	110.6	45	609	66		9.2	13.5	2
25	Dontrell Moore D. Moore	4,973	48	1,028	4.8	103.6	51	857	92		9.3	17.9	8