Sergio Ramos has made the most career appearances by a defender in the Champions League, with 142 appearances.

	NAME	M	START	MIN	G	A	YC	RC
1	Sergio Ramos S. Ramos	142	142	12,478	17	4	44	4
2	Paolo Maldini P. Maldini	135	130	11,422	3		18	0
3	Gerard Piqué G. Piqué	128	123	10,631	16	0	30	2
4	David Alaba D. Alaba	125	113	10,088	6	12	9	0
5	Marquinhos	122	120	10,617	11	4	14	0
6	Carles Puyol C. Puyol	115	109	9,618	2		25	1
7	Philipp Lahm P. Lahm	112	110	9,799	0	2	11	0
8	Dani Alves D. Alves	111	108	9,717	12	11	27	0
9	Gary Neville G. Neville	110	103	9,037	2		9	0
10	John Terry J. Terry	109	109	9,626	10	1	18	1
11	Patrice Evra P. Evra	108	100	8,974	2	0	21	0
12	Ashley Cole A. Cole	108	103	9,169	1	0	15	1
13	Roberto Carlos R. Carlos	107	107	9,361	16		17	0
14	Thiago Silva T. Silva	105	100	8,866	4	1	9	0
15	Marcelo	102	89	8,046	9	14	18	1
16	Pepe	102	96	8,677	3	1	24	2
17	Alessandro Nesta A. Nesta	99	98	8,495	0		20	1
18	Nicolás Otamendi N. Otamendi	97	94	8,360	2	2	25	1
19	Javier Zanetti J. Zanetti	97	91	8,265	2		6	0
20	Dani Carvajal D. Carvajal	96	86	7,655	2	17	22	1
21	Rio Ferdinand R. Ferdinand	93	91	8,184	2		11	0
22	Raphaël Varane R. Varane	92	84	7,536	2	1	9	0
23	Mats Hummels M. Hummels	90	85	7,432	5	1	16	1
24	Alessandro Costacurta A. Costacurta	90	80	7,009	0		14	1
25	Leonardo Bonucci L. Bonucci	88	84	7,566	3	2	13	0