Since 2019-20, Manchester United had their lowest goal differential in the Premier League against Liverpool, with a differential of -19 goals.

manchester united worst goal differential by opponent in the last 5 seasons

OPP	GD	M	W	D	L	G	GC	XG	XGA	SH	SOT	PASS-ATT	PASS	POSS%	FOUL	YC	RC
Liverpool	-19	10	1	4	5	7	26	10.08	23.26	91	32	3,570	2,672	36.9	90	32	2
Man City	-7	10	4	1	5	13	20	9.67	18.94	82	40	3,626	2,917	34.0	113	21	0
Arsenal	-6	10	2	2	6	11	17	11.23	15.66	116	42	4,624	3,843	48.7	116	23	0
Crystal Palace	-5	10	3	2	5	8	13	12.98	9.45	148	35	5,961	5,083	64.1	124	19	1
Watford	-2	4	1	1	2	4	6	7.58	4.79	69	23	2,357	1,937	62.6	24	4	1
West Brom	1	2	1	1	0	2	1	2.83	1.53	27	14	1,324	1,133	68.1	22	1	0
Luton Town	2	2	2	0	0	3	1	4.09	2.04	36	13	965	796	53.1	30	5	0
Tottenham	2	10	5	3	2	19	17	14.61	12.84	137	58	4,679	3,866	47.6	108	21	1
Brentford	3	6	4	1	1	10	7	7.49	8.67	87	30	3,396	2,890	61.7	60	10	0
Fulham	3	6	4	1	1	9	6	8.82	6.89	96	42	3,076	2,588	55.3	65	9	0
Brighton	3	10	6	0	4	17	14	13.21	15.63	147	57	4,907	4,106	50.9	104	25	0
Bournemouth	3	6	3	1	2	11	8	8.85	6.88	100	30	3,571	3,013	61.8	56	6	0
West Ham	4	10	6	1	3	12	8	13.00	11.70	143	45	5,865	5,048	58.6	104	16	0
Leicester City	4	8	4	2	2	13	9	12.44	9.38	94	34	4,023	3,315	50.4	105	15	0
Nottm Forest	5	4	3	0	1	9	4	8.55	2.94	67	30	2,350	1,988	63.9	46	13	0
Burnley	6	8	5	2	1	12	6	15.18	6.98	146	53	4,175	3,459	59.3	77	10	0
Aston Villa	6	10	6	2	2	19	13	15.20	11.12	160	59	4,803	4,033	54.8	136	24	0
Sheffield Utd	6	6	4	1	1	16	10	11.36	6.31	95	41	3,938	3,393	66.1	55	7	0
Wolves	7	10	7	2	1	13	6	15.08	9.83	142	45	5,199	4,424	53.9	98	27	0
Norwich City	8	4	4	0	0	11	3	9.81	3.73	67	31	2,238	1,914	57.2	52	3	0
Newcastle	8	10	5	2	3	19	11	13.34	12.51	157	57	5,567	4,711	61.5	112	19	0
Everton	9	10	5	4	1	18	9	15.70	11.25	155	60	5,509	4,609	59.3	118	14	0
Chelsea	9	10	4	5	1	18	9	17.20	15.54	132	50	4,240	3,421	43.0	118	26	0
Southampton	11	8	3	5	0	18	7	14.25	7.41	116	54	3,918	3,160	55.6	92	17	1
Leeds United	12	6	4	2	0	19	7	11.51	6.30	108	47	2,743	2,198	54.1	67	8	0