Lionel Messi has the most goals in the Champions League in a season versus Arsenal, with 4 goals in 2009-10.

most against arsenal goals by a player this season

	NAME	G	SEASON	CLUB	M	MIN	START	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Lionel Messi L. Messi	4	2009-10	Barcelona	2	177	2	2.00			0
2	Lionel Messi L. Messi	3	2015-16	Barcelona	2	180	2	1.50	0	3	1		12	5		214		1
3	Isaías	3	1991-92	Benfica	2	179	2	1.50			0
4	Arjen Robben A. Robben	2	2016-17	Bayern	2	159	2	1.00	0	2	0	0	9	6	0	126	12	1
5	Thiago Alcântara T. Alcântara	2	2016-17	Bayern	2	169	2	1.00	1	3	0	0	3	2	0	178	8	0
6	Robert Lewandowski R. Lewandowski	2	2016-17	Bayern	2	176	2	1.00	1	3	1	0	9	3	2	76	18	5
7	Arturo Vidal A. Vidal	2	2016-17	Bayern	2	180	2	1.00	0	2	0	0	7	4	0	220	7	0
8	Edinson Cavani E. Cavani	2	2016-17	PSG	2	180	2	1.00	0	2	0	0	11	3	0	60	13	3
9	Thomas Müller T. Müller	2	2015-16	Bayern	2	180	2	1.00	0	2	0		5	4		103		0
10	Anthony Vanden Borre A. Vanden Borre	2	2014-15	Anderlecht	2	180	2	1.00	0	2	1
11	Klaas-Jan Huntelaar K. Huntelaar	2	2012-13	Schalke	2	178	2	1.00			0
12	Kostas Mitroglou K. Mitroglou	2	2012-13	Olympiacos	2	108	1	1.00			0
13	Robinho	2	2011-12	Milan	2	174	2	1.00			0
14	David Fuster D. Fuster	2	2011-12	Olympiacos	2	144	2	1.00			0
15	Lionel Messi L. Messi	2	2010-11	Barcelona	2	180	2	1.00			1
16	Eduardo da Silva E. da Silva	2	2010-11	Shaktar	2	116	1	1.00			0
17	Cleverson Cordova C. Cordova	2	2010-11	Partizan	2	180	2	1.00			1
18	Matheus Nascimento M. Nascimento	2	2010-11	Braga	2	150	2	1.00			0
19	Zlatan Ibrahimovic Z. Ibrahimovic	2	2009-10	Barcelona	1	77	1	2.00			0
20	Cristiano Ronaldo C. Ronaldo	2	2008-09	Man United	2	180	2	1.00			0
21	Claudio Pizarro C. Pizarro	2	2004-05	Bayern	2	158	2	1.00			0
22	John Carew J. Carew	2	2002-03	Valencia	2	179	2	1.00			0
23	Antonio Cassano A. Cassano	2	2002-03	Roma	2	127	2	1.00			0
24	Tomáš Rosický T. Rosický	2	2002-03	Dortmund	1	89	1	2.00			1
25	Marcos Cipriano M. Cipriano	2	2000-01	Spartak	1	90	1	2.00			0