Daniele De Rossi has made the most career appearances by a Roma player in the Champions League, with 61 appearances.

most appearance by a player in roma history

	NAME	M	MIN	START	G	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Daniele De Rossi D. De Rossi	61	5,054	57	8	0.13	1	9	2
2	Francesco Totti F. Totti	57	4,560	53	17	0.30	1	18	4
3	Christian Panucci C. Panucci	38	3,238	37	5	0.13			0
4	Alessandro Florenzi A. Florenzi	32	2,325	25	1	0.03	1	2	0	0	24	10	0	1,404		2
5	Kostas Manolas K. Manolas	32	2,820	31	3	0.09	1	4	0	0	19	9	0	1,480		0
6	Simone Perrotta S. Perrotta	31	2,519	28	2	0.06			0
7	Philippe Mexès P. Mexès	31	2,655	31	1	0.03			0
8	Doni	29	2,610	29	0	0.00			0
9	David Pizarro D. Pizarro	27	1,712	18	2	0.07			0
10	Mirko Vučinić M. Vučinić	27	1,539	16	8	0.30			0
11	Edin Džeko E. Džeko	25	2,128	23	15	0.60	7	22	0	0	90	37	2	917		12
12	Vincenzo Montella V. Montella	25	1,112	11	2	0.08			0
13	Radja Nainggolan R. Nainggolan	24	2,076	24	2	0.08	5	7	1	0	39	17	1	981		3
14	Marco Cassetti M. Cassetti	24	1,900	22	1	0.04			0
15	Taddei	24	1,880	23	3	0.13			0
16	Vincent Candela V. Candela	23	2,041	23	0	0.00			0
17	Cafu	22	1,883	22	2	0.09			0
18	Wálter Samuel W. Samuel	22	1,980	22	0	0.00			0
19	Emerson	22	1,980	22	3	0.14			0
20	Francisco Lima F. Lima	22	1,721	20	0	0.00			0
21	Mancini	21	1,763	21	3	0.14			0
22	Aleksandar Kolarov A. Kolarov	20	1,741	19	1	0.05	4	5	0	0	30	10	1	1,606	33	1
23	Max Tonetto M. Tonetto	19	1,478	16	0	0.00			0
24	Alberto Aquilani A. Aquilani	19	1,217	15	0	0.00			0
25	Antonio Cassano A. Cassano	19	1,086	12	5	0.26			0