Lionel Messi has made the most career appearances by an Argentine in the Champions League, with 163 appearances.

	NAME	M	MIN	START	G	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Lionel Messi L. Messi	163	13,585	150	129	0.79	23	152	18
2	Ángel di María Á. di María	116	7,979	91	24	0.21	24	48	1
3	Nicolás Otamendi N. Otamendi	102	8,802	99	2	0.02	2	4	0
4	Javier Zanetti J. Zanetti	97	8,265	91	2	0.02			0
5	Javier Mascherano J. Mascherano	96	8,077	90	0	0.00	1	1	0
6	Gonzalo Higuaín G. Higuaín	83	5,365	61	24	0.29	4	28	2
7	Sergio Agüero S. Agüero	79	5,178	58	41	0.52	6	47	11
8	Esteban Cambiasso E. Cambiasso	79	6,154	70	6	0.08	0	6	0
9	Ángel Correa Á. Correa	78	3,184	28	6	0.08	4	10	0	0	100	39	4	1,933		17
10	Wálter Samuel W. Samuel	72	6,166	70	3	0.04	0	3	0
11	Martín Demichelis M. Demichelis	67	5,209	58	3	0.04	0	3	0
12	Lautaro Martínez L. Martínez	66	4,381	53	25	0.38	6	31	2	0	184	74	10	1,840	294	28
13	Hernán Crespo H. Crespo	65	4,262	49	25	0.38			0
14	Lucho González L. González	63	5,097	59	18	0.29			3
15	Santiago Solari S. Solari	61	2,666	26	7	0.11			0
16	Juan Sebastián Verón J. Sebastián Verón	60	4,896	57	7	0.12			0
17	Alfredo Di Stéfano A. Di Stéfano	58	5,216	58	49	0.84			3
18	Javier Saviola J. Saviola	56	3,553	43	18	0.32			0
19	Lionel Scaloni L. Scaloni	54	3,037	30	2	0.04			0
20	Paulo Dybala P. Dybala	53	3,172	37	18	0.34	4	22	3	1	127	50	4	2,409		13
21	Julio Cruz J. Cruz	48	2,884	31	19	0.40			1
22	Lisandro López L. López	47	3,827	42	19	0.40			1
23	Nicolás Gaitán N. Gaitán	46	3,124	37	5	0.11	3	8	0
24	Carlos Tévez C. Tévez	46	3,037	32	13	0.28	3	16	1
25	Mauricio Pellegrino M. Pellegrino	45	3,980	44	0	0.00			0

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