Since 2005-06, Samir Handanovič has made the most appearances in Serie A, with 563 appearances.

most games by a player after 2005

	NAME	M	MIN	START	G	G/M	A	G+A	PK
1	Samir Handanovič S. Handanovič	563	50,335	563	0	0.00	0	0	0
2	Fabio Quagliarella F. Quagliarella	551	37,901	432	182	0.33	34	216	32
3	Andrea Consigli A. Consigli	510	45,538	510	0	0.00	0	0	0
4	Antonio Candreva A. Candreva	502	36,702	424	85	0.17	79	164	22
5	Lorenzo De Silvestri L. De Silvestri	456	33,265	378	27	0.06	22	49	0
6	Goran Pandev G. Pandev	448	25,969	295	97	0.22	27	124	2
7	Leonardo Bonucci L. Bonucci	436	36,567	404	32	0.07	4	36	3
8	Francesco Acerbi F. Acerbi	415	35,502	394	24	0.06	9	33	1
9	Marek Hamšík M. Hamšík	408	31,477	375	100	0.25	64	164	7
10	Daniele De Rossi D. De Rossi	408	33,907	391	39	0.10	21	60	4
11	Juan Cuadrado J. Cuadrado	405	27,812	302	44	0.11	63	107	2
12	Piotr Zieliński P. Zieliński	400	24,017	261	45	0.11	52	97	3
13	Giorgio Chiellini G. Chiellini	393	33,035	374	24	0.06	15	39	0
14	Giacomo Bonaventura G. Bonaventura	380	27,347	313	65	0.17	40	105	0
15	Massimo Gobbi M. Gobbi	375	28,958	322	9	0.02	17	26	0
16	Sergio Pellissier S. Pellissier	373	24,334	262	97	0.26	19	116	17
17	Antonio Mirante A. Mirante	372	32,889	369	0	0.00	1	1	0
18	Sergio Floccari S. Floccari	370	22,648	247	74	0.20	7	81	5
19	Radja Nainggolan R. Nainggolan	367	29,575	336	48	0.13	37	85	0
20	Luca Cigarini L. Cigarini	362	25,721	295	18	0.05	27	45	3
21	Alberto Gilardino A. Gilardino	362	27,347	307	130	0.36	13	143	8
22	Paulo Dybala P. Dybala	359	24,349	282	130	0.36	67	197	33
23	Rodrigo Palacio R. Palacio	357	25,804	288	93	0.26	51	144	4
24	Giampaolo Pazzini G. Pazzini	357	21,114	214	109	0.31	8	117	24
25	Manuel Pasqual M. Pasqual	356	28,790	322	10	0.03	25	35	2