Carlo Reguzzoni has scored the most career goals by a midfielder in Serie A, with 156 goals.

	NAME	G	M	MIN	START	G/M	A	G+A	PK
1	Carlo Reguzzoni C. Reguzzoni	156	400	35,865	400	0.39			19
2	Adriano Bassetto A. Bassetto	149	329	29,610	329	0.45			12
3	Gianni Rivera G. Rivera	129	526	46,999	525	0.25			27
4	Antonio Vojak A. Vojak	107	208	18,720	208	0.51			20
5	Marek Hamšík M. Hamšík	100	409	31,502	375	0.24	64	164	7
6	Lorenzo Insigne L. Insigne	96	336	23,961	278	0.29	75	171	27
7	Josip Iličić J. Iličić	96	339	21,792	251	0.28	59	155	13
8	Gian Carlo Vitali G. Carlo Vitali	89	300	26,910	300	0.30			1
9	Antonio Candreva A. Candreva	85	502	36,702	424	0.17	79	164	22
10	Paolo Barison P. Barison	85	292	26,015	290	0.29			7
11	Nils Erik Liedholm N. Erik Liedholm	81	359	32,310	359	0.23			25
12	Luciano Chiarugi L. Chiarugi	80	290	25,063	280	0.28			5
13	Enrico Aldo Candiani E. Aldo Candiani	80	231	20,790	231	0.35			8
14	Mario Corso M. Corso	78	436	38,890	436	0.18			4
15	Cristiano Doni C. Doni	76	265	20,507	234	0.29			19
16	Atilio José Demaría A. José Demaría	76	268	24,030	268	0.28			11
17	Egisto Pandolfini E. Pandolfini	75	316	28,440	316	0.24			17
18	Francesco Pernigo F. Pernigo	75	212	19,080	212	0.35			10
19	Vittorio Sentimenti V. Sentimenti	75	362	32,310	362	0.21			15
20	Giovanni Busoni G. Busoni	75	164	14,760	164	0.46			0
21	Pavel Nedvěd P. Nedvěd	73	352	28,599	330	0.21			0
22	João Pedro J. Pedro	71	218	16,954	190	0.33	19	90	15
23	Michel Platini M. Platini	70	147	13,021	146	0.48			10
24	Francisco Loiácono F. Loiácono	70	208	18,495	208	0.34			8
25	Mario Tortul M. Tortul	70	252	22,410	252	0.28			14