Between the 2009-10 and 2018-19 seasons, Antonio Di Natale scored the most goals in Serie A, with 136 goals.

	NAME	G	M	MIN	START	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Antonio Di Natale A. Di Natale	136	228	17,651	202	0.60	27	163	25
2	Mauro Icardi M. Icardi	121	219	17,197	193	0.55	27	148	19
3	Gonzalo Higuaín G. Higuaín	117	192	15,241	173	0.61	25	142	12
4	Fabio Quagliarella F. Quagliarella	112	293	20,781	241	0.38	27	139	23
5	Ciro Immobile C. Immobile	99	187	14,282	160	0.53	26	125	19
6	Edinson Cavani E. Cavani	91	138	11,406	128	0.66	12	103	17
7	Dries Mertens D. Mertens	84	205	12,517	130	0.41	40	124	10
8	Marek Hamšík M. Hamšík	82	339	26,085	310	0.24	64	146	5
9	Rodrigo Palacio R. Palacio	81	286	20,777	232	0.28	43	124	4
10	Alessandro Matri A. Matri	80	272	15,257	167	0.29	14	94	6
11	Alberto Gilardino A. Gilardino	75	233	17,848	199	0.32	13	88	7
12	Paulo Dybala P. Dybala	73	189	13,325	150	0.39	34	107	16
13	Josip Iličić J. Iličić	72	265	17,752	205	0.27	42	114	11
14	Giampaolo Pazzini G. Pazzini	72	229	14,297	144	0.31	8	80	18
15	Francesco Totti F. Totti	72	200	13,434	156	0.36	46	118	27
16	Mattia Destro M. Destro	70	218	13,519	152	0.32	12	82	2
17	Andrea Belotti A. Belotti	69	177	12,985	140	0.39	19	88	12	0	456	175	17	5,560	550	134
18	Cyril Théréau C. Théréau	66	259	18,362	214	0.25	17	83	8
19	Luca Toni L. Toni	66	167	12,182	136	0.40	16	82	11
20	Marco Borriello M. Borriello	65	209	13,437	151	0.31	16	81	6
21	Gustavo Denis G. Denis	65	207	14,971	166	0.31	15	80	14
22	Duván Zapata D. Zapata	63	168	10,857	120	0.38	18	81	2
23	Edin Džeko E. Džeko	62	137	10,603	115	0.45	24	86	3	0	544	222	19	4,895	726	73
24	Diego Milito D. Milito	62	128	9,047	103	0.48	11	73	15
25	Sergio Pellissier S. Pellissier	62	265	16,550	175	0.23	19	81	12