Enrique Omar Sívori and Silvio Piola are tied for having the most goals in a Serie A match, with 6 goals.

	NAME	G	DATE	CLUB		OPP	RATING	MIN	A	XG	XA	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF	FOUL	YC	RC
1	Enrique Omar Sívori E. Omar Sívori	6	6/10/1961	Juventus	vs	Inter		90				1									0	0
2	Silvio Piola S. Piola	6	10/29/1933	Pro Vercelli	vs	Fiorentina		90				0									0	0
3	Miroslav Klose M. Klose	5	5/5/2013	Lazio	vs	Bologna		68	0			0									0	0
4	Roberto Pruzzo R. Pruzzo	5	2/16/1986	Roma	vs	Avellino		90				2									0	0
5	Kurt Roland Hamrin K. Roland Hamrin	5	2/2/1964	Fiorentina	@	Atalanta		90				0									0	0
6	Antonio Valentín Angelillo A. Valentín Angelillo	5	10/12/1958	Inter	vs	SPAL		90				0									0	0
7	Giancarlo Galli G. Galli	5	4/13/1958	Milan	vs	Lazio		90				1									0	0
8	Emanuele Del Vecchio E. Del Vecchio	5	2/9/1958	Verona	vs	Sampdoria		90				0									0	0
9	Bruno Ispiro B. Ispiro	5	5/8/1949	Triestina	vs	Padova		90				0									0	0
10	István Mike Mayer I. Mike Mayer	5	2/6/1949	Bologna	vs	Livorno		90				1									0	0
11	Guglielmo Gabetto G. Gabetto	5	12/17/1939	Juventus	vs	Bari		90				0									0	0
12	Giuseppe Meazza G. Meazza	5	1/9/1938	Inter	vs	Bari		90				0									0	0
13	Cesare Augusto Fasanelli C. Augusto Fasanelli	5	5/3/1931	Roma	vs	Livorno		90				0									0	0
14	Giovanni Vecchina G. Vecchina	5	3/30/1930	Padova	vs	Pro Patria		90				0									0	0
15	Italo Rossi I. Rossi	5	1/19/1930	Pro Patria	vs	Roma		90				0									0	0
16	Mateo Retegui M. Retegui	4	2/8/2025	Atalanta	@	Verona	9.8	90	0	1.69	0.09	0	0	7	4	0	39	7	0	0	0	0
17	Lautaro Martínez L. Martínez	4	9/30/2023	Inter	@	Salernitana	9.7	35	0	1.52	0.02	1	0	5	5	0	28	4	0	2	0	0
18	Giovanni Simeone G. Simeone	4	10/24/2021	Verona	vs	Lazio		90	0	1.13	0.34	0	0	4	4	0	46	10	2	1	0	0
19	Duván Zapata D. Zapata	4	1/20/2019	Atalanta	@	Frosinone		90	0			0	0	9	5	0	52	14	0	3	0	0
20	Mauro Icardi M. Icardi	4	3/18/2018	Inter	@	Sampdoria		66	0			1	0	6	4	0	14	10	1	1	0	0
21	Ciro Immobile C. Immobile	4	1/6/2018	Lazio	@	SPAL		90	0			0	0	4	4	0	49	6	1	1	0	0
22	Marco Parolo M. Parolo	4	2/5/2017	Lazio	@	Pescara		90	0			0	0	6	5	0	61	5	0	1	0	0
23	Dries Mertens D. Mertens	4	12/18/2016	Napoli	vs	Torino		90	0			1	0	7	5	0	59	11	0	1	0	0
24	Domenico Berardi D. Berardi	4	1/12/2014	Sassuolo	vs	Milan		78	0			0									0	0
25	Mauro Icardi M. Icardi	4	1/27/2013	Sampdoria	vs	Pescara		74	0			0									0	0