Francesco Acerbi had the most interceptions in Serie A in 2015-16, with 139 interceptions.

	NAME	INT	M	MIN	START	G	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Francesco Acerbi F. Acerbi	139	36	3,240	36	4	0.11	0	4	0	0	13	8	0	2,334	0	2
2	Marten de Roon M. de Roon	132	36	3,094	35	1	0.03	2	3	0	0	20	6	0	2,189	0	0
3	Armando Izzo A. Izzo	120	33	2,657	30	0	0.00	1	1	0	0	15	5	0	1,965	0	4
4	Riccardo Montolivo R. Montolivo	114	31	2,689	31	0	0.00	1	1	0	0	29	5	1	2,417	0	0
5	Riccardo Gagliolo R. Gagliolo	107	31	2,635	29	1	0.03	0	1	0	0	13	4	0	1,688	1	1
6	Federico Peluso F. Peluso	99	34	3,038	34	1	0.03	1	2	0	0	20	4	0	2,141	0	5
7	Fernando	96	35	2,983	34	4	0.11	2	6	0	1	48	13	3	2,724	0	1
8	Davide Astori D. Astori	95	33	2,901	32	0	0.00	0	0	0	0	12	2	0	2,781	1	0
9	Nicolás Burdisso N. Burdisso	93	28	2,447	28	0	0.00	0	0	0	0	10	3	0	1,442	0	0
10	Mário Rui M. Rui	93	36	3,239	36	0	0.00	3	3	0	0	29	4	1	2,913	0	2
11	Andrea Costa A. Costa	92	24	2,080	23	1	0.04	0	1	0	0	6	2	0	1,701	0	2
12	Amadou Diawara A. Diawara	91	34	2,732	31	0	0.00	1	1	0	0	20	1	0	2,008	0	0
13	Gaetano Letizia G. Letizia	91	35	2,894	33	1	0.03	0	1	0	0	24	3	1	2,158	1	1
14	Andrea Masiello A. Masiello	91	29	2,400	27	0	0.00	1	1	0	0	4	0	0	1,602	0	3
15	Francesco Magnanelli F. Magnanelli	90	34	3,060	34	1	0.03	1	2	0	0	19	4	0	2,918	0	1
16	Kamil Glik K. Glik	89	33	2,970	33	0	0.00	1	1	0	0	19	7	0	2,120	0	1
17	Luca Rossettini L. Rossettini	88	29	2,542	28	3	0.10	1	4	0	0	14	4	0	1,675	0	1
18	Gonzalo Rodríguez G. Rodríguez	87	35	3,142	35	4	0.11	0	4	0	0	12	5	0	2,684	0	1
19	Felipe	87	26	2,145	26	1	0.04	1	2	0	0	11	5	1	1,226	0	1
20	Cristian Zaccardo C. Zaccardo	86	27	2,404	26	1	0.04	0	1	0	0	17	9	0	1,317	0	7
21	Lucas Castro L. Castro	86	34	2,787	32	3	0.09	0	3	0	0	45	11	0	1,778	0	2
22	Danilo	85	34	2,945	34	0	0.00	0	0	0	0	14	5	0	1,639	0	5
23	Maurício	85	24	1,916	19	0	0.00	0	0	0	0	10	0	0	1,303	1	1
24	Adam Masina A. Masina	84	33	2,622	30	2	0.06	4	6	0	0	14	3	0	2,047	0	5
25	Alessio Romagnoli A. Romagnoli	84	34	2,942	33	0	0.00	0	0	0	0	6	0	0	1,943	0	3

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StatMuse has Serie A data for interceptions going back to the 2014-15 season.

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1	Roma	5	4	1	0	11	13
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3	Lazio	5	4	1	0	5	13
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5	Milan	5	3	2	0	6	11
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9	Napoli	5	2	1	2	1	7
10	Sassuolo	5	2	1	2	0	7
11	Atalanta	5	2	0	3	-2	6
12	Lecce	5	2	0	3	-5	6
13	Udinese	5	1	1	3	-3	4
14	Torino	5	1	1	3	-3	4
15	Parma	5	1	1	3	-3	4
16	Monza	5	1	1	3	-4	4
17	Fiorentina	5	1	1	3	-6	4
18	Bologna	5	0	2	3	-3	2
19	Genoa	5	0	1	4	-7	1
20	Venezia	5	0	0	5	-9	0