Alan Shearer has the most career combined goals and assists in the Premier League against Big Six opponents, with 75.

most pl goals and assists by a player vs big 6 in premier league history

	NAME	G+A	M	MIN	START	G	G/M	A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Alan Shearer A. Shearer	75	129	11,314	126	56	0.43	19	7
2	Mohamed Salah M. Salah	72	78	6,442	73	50	0.64	22	11
3	Wayne Rooney W. Rooney	59	135	10,635	117	45	0.33	14	6
4	Ryan Giggs R. Giggs	59	170	12,423	138	18	0.11	41	2
5	Jamie Vardy J. Vardy	55	108	8,408	95	45	0.42	10	8	0	188	92	8	2,258	328	88
6	Sergio Agüero S. Agüero	52	75	5,630	69	44	0.59	8	6
7	Jimmy Floyd Hasselbaink J. Floyd Hasselbaink	52	81	5,793	66	41	0.51	11	3
8	Harry Kane H. Kane	48	81	7,007	78	39	0.48	9	11
9	Thierry Henry T. Henry	47	61	5,181	57	34	0.56	13	3
10	Frank Lampard F. Lampard	47	158	12,798	144	26	0.16	21	10
11	Dion Dublin D. Dublin	47	92	7,047	79	34	0.37	13	5
12	Steven Gerrard S. Gerrard	45	129	10,736	123	22	0.17	23	8
13	Andy Cole A. Cole	45	109	8,470	95	32	0.29	13	0
14	Les Ferdinand L. Ferdinand	44	93	6,907	78	31	0.33	13	0
15	Robbie Fowler R. Fowler	43	90	6,386	70	33	0.37	10	3
16	Kevin De Bruyne K. De Bruyne	42	77	5,896	67	23	0.30	19	2
17	Kevin Davies K. Davies	40	138	10,884	124	22	0.16	18	1
18	Robin van Persie R. van Persie	39	75	5,554	61	28	0.37	11	3
19	Didier Drogba D. Drogba	39	68	4,800	51	21	0.31	18	0
20	Sadio Mané S. Mané	38	79	6,196	71	29	0.37	9	0	0	153	76	4	3,686	286	65
21	Cesc Fàbregas C. Fàbregas	38	96	7,390	82	9	0.09	29	0
22	Teddy Sheringham T. Sheringham	37	106	7,846	88	25	0.24	12	5
23	Matt Le Tissier M. Le Tissier	37	78	5,572	62	21	0.27	16	3
24	Marcus Rashford M. Rashford	36	82	5,719	64	27	0.33	9	4	0	130	65	6	2,436	274	39
25	Son Heung-min S. Heung-min	36	88	6,420	76	27	0.31	9	1	0	173	79	5	3,170	289	59