Javier Zanetti has made the most career appearances by an Inter player in Serie A, with 615 appearances.

	NAME	M	MIN	START	G	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Javier Zanetti J. Zanetti	615	53,018	589	12	0.02	6	18	0
2	Giuseppe Bergomi G. Bergomi	519	45,012	510	23	0.04			0
3	Giacinto Facchetti G. Facchetti	475	42,717	475	59	0.12			0
4	Alessandro Mazzola A. Mazzola	417	37,350	417	118	0.28			11
5	Mario Corso M. Corso	413	36,901	413	75	0.18			3
6	Giuseppe Baresi G. Baresi	392	31,529	340	10	0.03			0
7	Samir Handanovič S. Handanovič	380	33,954	380	0	0.00	0	0	0
8	Tarcisio Burgnich T. Burgnich	357	31,978	357	5	0.01			0
9	Walter Zenga W. Zenga	328	29,349	328	0	0.00			0
10	Iván Córdoba I. Córdoba	323	26,808	297	15	0.05	0	15	0
11	Alessandro Altobelli A. Altobelli	317	27,643	310	129	0.41			24
12	Esteban Cambiasso E. Cambiasso	315	25,710	290	41	0.13	9	50	0
13	Benito Lorenzi B. Lorenzi	305	27,270	305	138	0.45			0
14	Giuseppe Meazza G. Meazza	303	27,027	303	198	0.65			11
15	Riccardo Ferri R. Ferri	290	24,532	277	6	0.02			0
16	Ivano Bordon I. Bordon	281	24,805	272	0	0.00			0
17	Gabriele Oriali G. Oriali	277	23,897	274	35	0.13			0
18	Aristide Guarneri A. Guarneri	271	24,306	269	4	0.01			0
19	Atilio José Demaría A. José Demaría	268	24,030	268	76	0.28			11
20	Marcelo Brozović M. Brozović	261	19,768	223	25	0.10	36	61	0	1	329	90	9	20,264	210	5
21	Gianpiero Marini G. Marini	256	21,844	242	10	0.04			0
22	Luis Suárez L. Suárez	256	22,995	256	42	0.16			10
23	Gino Armano G. Armano	255	22,950	255	72	0.28			11
24	Aldo Campatelli A. Campatelli	249	22,365	249	39	0.16			7
25	Lautaro Martínez L. Martínez	246	17,161	197	118	0.48	28	146	11	0	777	297	20	7,518	1,318	96