Romelu Lukaku has 9 goals and 2 assists in 13 appearances versus Southampton in the Premier League in his career.
| NAME | DATE | CLUB | OPP | RTG | MIN | G | A | XG | XA | PK | FK | SH | SOT | WOOD | TCH | TCH-BOX | OFF | FOUL | YC | RC | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Lukaku | 11/5/2012 |  West Brom | vs |  Southampton | 19 | 0 | 0 | 0 | 0 | 0 | |||||||||||
| 2 | | R. Lukaku | 4/27/2013 | West Brom | @ | Southampton | 85 | 1 | 1 | 0 | 0 | 0 | |||||||||||
| 3 |  | R. Lukaku | 12/29/2013 |  Everton | vs | Southampton | 90 | 1 | 0 | 0 | 0 | 0 | |||||||||||
| 4 | | R. Lukaku | 4/26/2014 | Everton | @ | Southampton | 90 | 0 | 0 | 0 | 0 | 0 | |||||||||||
| 5 | | R. Lukaku | 12/20/2014 | Everton | @ | Southampton | 90 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 49 | 0 | 2 | 0 | 0 | 0 | |||
| 6 | | R. Lukaku | 8/15/2015 | Everton | @ | Southampton | 89 | 2 | 0 | 0 | 0 | 3 | 2 | 0 | 47 | 0 | 0 | 1 | 0 | 0 | |||
| 7 | | R. Lukaku | 11/27/2016 | Everton | @ | Southampton | 90 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 35 | 2 | 0 | 0 | 1 | 0 | |||
| 8 | | R. Lukaku | 1/2/2017 | Everton | vs | Southampton | 90 | 1 | 1 | 0 | 0 | 5 | 3 | 0 | 49 | 6 | 3 | 0 | 0 | 0 | |||
| 9 |  | R. Lukaku | 9/23/2017 |  Man United | @ | Southampton | 90 | 1 | 0 | 0 | 0 | 3 | 3 | 0 | 44 | 5 | 0 | 3 | 1 | 0 | |||
| 10 | | R. Lukaku | 12/30/2017 | Man United | vs | Southampton | 14 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | |||
| 11 | | R. Lukaku | 12/1/2018 | Man United | @ | Southampton | 86 | 1 | 0 | 0 | 0 | 2 | 2 | 0 | 37 | 3 | 1 | 0 | 0 | 0 | |||
| 12 | | R. Lukaku | 3/2/2019 | Man United | vs | Southampton | 90 | 2 | 0 | 0 | 0 | 5 | 4 | 0 | 44 | 8 | 0 | 2 | 1 | 0 | |||
| 13 |  | R. Lukaku | 10/2/2021 |  Chelsea | vs | Southampton | 6.2 | 90 | 0 | 0 | 0.74 | 0.01 | 0 | 0 | 2 | 0 | 1 | 24 | 3 | 1 | 0 | 0 | 0 |
| Total | 1,013 | 9 | 2 | 0 | 3 | 0 |
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