Sampdoria earned their most points in Serie A in a season in 2009-10, with 67 points.

	CLUB	POINTS	SEASON	M	W	D	L	G	GC	SH	SOT	PASS-ATT	PASS	POSS%	FOUL	YC	RC
1	Sampdoria	67	2009-10	38	19	10	9	49	41							94	8
2	Sampdoria	61	2004-05	38	17	10	11	42	29							86	4
3	Sampdoria	60	2007-08	38	17	9	12	56	46							104	6
4	Sampdoria	56	2014-15	38	13	17	8	48	42	503	156	15,104	12,079	48.0	614	103	3
5	Sampdoria	54	2017-18	38	16	6	16	56	60	482	175	18,619	15,346	53.7	426	69	3
6	Sampdoria	53	2018-19	38	15	8	15	60	51	487	179	19,435	16,166	55.3	493	92	3
7	Sampdoria	53	1996-97	34	14	11	9	60	46							74	9
8	Sampdoria	52	2020-21	38	15	7	16	52	54	427	141	15,810	12,412	45.1	509	83	3
9	Sampdoria	52	1995-96	34	14	10	10	59	47							68	5
10	Sampdoria	51	1990-91	34	20	11	3	57	24							38	3
11	Sampdoria	50	1994-95	34	13	11	10	51	37							45	5
12	Sampdoria	49	2006-07	38	13	10	15	44	48							94	7
13	Sampdoria	48	2016-17	38	12	12	14	49	55	505	167	17,840	14,275	52.3	514	75	4
14	Sampdoria	48	1997-98	34	13	9	12	52	55							83	14
15	Sampdoria	46	2008-09	38	11	13	14	49	52							102	4
16	Sampdoria	46	2003-04	34	11	13	10	40	42							78	3
17	Sampdoria	45	2013-14	38	12	9	17	48	62							112	10
18	Sampdoria	44	1993-94	34	18	8	8	64	39							46	3
19	Sampdoria	43	1989-90	34	16	11	7	46	26							57	3
20	Sampdoria	42	2019-20	38	12	6	20	48	65	560	175	14,198	10,990	42.5	563	111	7
21	Sampdoria	42	2012-13	38	11	10	17	43	51							91	9
22	Sampdoria	41	2005-06	38	10	11	17	47	51							93	5
23	Sampdoria	41	1960-61	34	17	7	10	54	51							0	2
24	Sampdoria	41	1951-52	38	16	9	13	48	40							0	2
25	Sampdoria	41	1948-49	38	16	9	13	74	63							0	3