11 players are tied for the most wins in the Premier League against Big Six opponents this season, with 5 wins. The first three are Donyell Malen, Emiliano Buendía and Emiliano Martínez.
| NAME | W | SEASON | CLUB | Rating | M | MIN | START | G | G/M | A | G+A | PK | FK | SH | SOT | WOOD | TCH | TCH-BOX | OFF | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | D. Malen | 5 | 2025-26 | 6.32 | 7 | 226 | 2 | 0 | 0.00 | 0 | 0 | 0 | 0 | 6 | 1 | 1 | 49 | 12 | 0 | |
| 2 | | E. Buendía | 5 | 2025-26 | 7.42 | 6 | 187 | 3 | 2 | 0.33 | 1 | 3 | 0 | 0 | 6 | 2 | 0 | 111 | 10 | 0 | |
| 3 |  | E. Martínez | 5 | 2025-26 | 6.60 | 7 | 630 | 7 | 0 | 0.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 379 | 0 | 0 | |
| 4 | | E. Konsa | 5 | 2025-26 | 7.10 | 7 | 630 | 7 | 0 | 0.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 443 | 2 | 0 | |
| 5 | | I. Maatsen | 5 | 2025-26 | 6.62 | 6 | 276 | 3 | 0 | 0.00 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 179 | 12 | 0 | |
| 6 | | J. McGinn | 5 | 2025-26 | 6.30 | 7 | 481 | 6 | 0 | 0.00 | 1 | 1 | 0 | 0 | 5 | 2 | 0 | 207 | 7 | 0 | |
| 7 | | M. Cash | 5 | 2025-26 | 6.90 | 6 | 536 | 6 | 2 | 0.33 | 0 | 2 | 0 | 0 | 8 | 3 | 1 | 325 | 5 | 0 | |
| 8 |  | M. Rogers | 5 | 2025-26 | 6.92 | 7 | 621 | 7 | 3 | 0.43 | 0 | 3 | 0 | 0 | 16 | 6 | 2 | 288 | 25 | 2 | |
| 9 |  | O. Watkins | 5 | 2025-26 | 7.18 | 7 | 450 | 5 | 3 | 0.43 | 1 | 4 | 0 | 0 | 17 | 7 | 1 | 170 | 38 | 2 | |
| 10 | | B. Kamara | 5 | 2025-26 | 6.99 | 6 | 529 | 6 | 0 | 0.00 | 1 | 1 | 0 | 0 | 2 | 1 | 0 | 343 | 5 | 0 | |
| 11 |  | A. Onana | 5 | 2025-26 | 6.98 | 7 | 495 | 6 | 0 | 0.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 292 | 2 | 0 | |
| 12 | | L. Digne | 4 | 2025-26 | 6.59 | 6 | 354 | 4 | 0 | 0.00 | 1 | 1 | 0 | 0 | 2 | 1 | 0 | 203 | 5 | 0 | |
| 13 | | V. Nilsson-Lindelöf | 3 | 2025-26 | 6.82 | 4 | 275 | 3 | 0 | 0.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 174 | 1 | 0 | |
| 14 | | Y. Tielemans | 3 | 2025-26 | 6.45 | 4 | 351 | 4 | 0 | 0.00 | 1 | 1 | 0 | 0 | 3 | 1 | 0 | 215 | 9 | 1 | |
| 15 | | L. Bogarde | 3 | 2025-26 | 6.37 | 4 | 117 | 1 | 0 | 0.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 92 | 0 | 0 | |
| 16 |  | J. Sancho | 3 | 2025-26 | 6.62 | 5 | 169 | 1 | 0 | 0.00 | 0 | 0 | 0 | 0 | 4 | 3 | 0 | 96 | 10 | 0 | |
| 17 | | P. Torres | 3 | 2025-26 | 6.89 | 4 | 338 | 4 | 0 | 0.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 215 | 2 | 0 | |
| 18 | | E. Guessand | 3 | 2025-26 | 6.39 | 4 | 142 | 2 | 0 | 0.00 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 42 | 5 | 0 | |
| 19 | | O. Hutchinson | 2 | 2025-26 | 6.73 | 3 | 210 | 2 | 1 | 0.33 | 0 | 1 | 0 | 0 | 7 | 3 | 0 | 113 | 10 | 2 | |
| 20 | | R. Barkley | 2 | 2025-26 | 6.41 | 3 | 58 | 0 | 0 | 0.00 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 34 | 2 | 0 | |
| 21 | | I. Jesus | 2 | 2025-26 | 6.28 | 5 | 381 | 4 | 0 | 0.00 | 1 | 1 | 0 | 0 | 10 | 1 | 1 | 156 | 23 | 5 | |
| 22 | | R. Lavia | 2 | 2025-26 | 6.70 | 2 | 51 | 0 | 0 | 0.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 33 | 2 | 0 | |
| 23 |  | A. Garnacho | 2 | 2025-26 | 7.00 | 3 | 184 | 2 | 0 | 0.00 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 86 | 13 | 0 | |
| 24 |  | J. Gittens | 2 | 2025-26 | 6.40 | 2 | 41 | 0 | 0 | 0.00 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 29 | 4 | 0 | |
| 25 | | F. Onyeka | 2 | 2025-26 | 6.70 | 3 | 29 | 0 | 0 | 0.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 19 | 0 | 0 | |
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| 1 | 20 | 15 | 3 | 2 | 26 | 48 | |
| 2 | 20 | 13 | 3 | 4 | 26 | 42 | |
| 3 | 20 | 13 | 3 | 4 | 9 | 42 | |
| 4 | 20 | 10 | 4 | 6 | 4 | 34 | |
| 5 | 20 | 8 | 7 | 5 | 11 | 31 | |
| 6 | 20 | 8 | 7 | 5 | 4 | 31 | |
| 7 | 20 | 9 | 3 | 8 | 4 | 30 | |
| 8 | 20 | 7 | 9 | 4 | 2 | 30 | |
| 9 | 20 | 8 | 5 | 7 | 4 | 29 | |
| 10 | 20 | 7 | 7 | 6 | 3 | 28 | |
| 11 | 20 | 8 | 4 | 8 | -1 | 28 | |
| 12 | 20 | 8 | 4 | 8 | -2 | 28 | |
| 13 | 20 | 7 | 6 | 7 | 4 | 27 | |
| 14 | 20 | 7 | 6 | 7 | -1 | 27 | |
| 15 | 20 | 5 | 8 | 7 | -7 | 23 | |
| 16 | 20 | 5 | 7 | 8 | -7 | 22 | |
| 17 | 20 | 5 | 3 | 12 | -14 | 18 | |
| 18 | 20 | 3 | 5 | 12 | -20 | 14 | |
| 19 | 20 | 3 | 3 | 14 | -19 | 12 | |
| 20 | 20 | 1 | 3 | 16 | -26 | 6 |
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