Iker Casillas has made the most career appearances by a Spaniard in the Champions League, with 177 appearances.

	NAME	M	MIN	START	G	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	OFF
1	Iker Casillas I. Casillas	177	15,817	176	0	0.00	0	0	0
2	Xavi	151	11,313	126	11	0.07	0	11	2
3	Sergio Ramos S. Ramos	142	12,478	142	17	0.12	4	21	3
4	Raúl	142	12,015	135	71	0.50			1
5	Andrés Iniesta A. Iniesta	130	9,236	106	11	0.08	9	20	0
6	Sergio Busquets S. Busquets	129	10,407	121	4	0.03	0	4	0
7	Gerard Piqué G. Piqué	128	10,631	123	16	0.13	0	16	0
8	Xabi Alonso X. Alonso	119	9,740	114	6	0.05	2	8	1
9	Koke	118	9,355	107	5	0.04	10	15	0
10	Carles Puyol C. Puyol	115	9,618	109	2	0.02			0
11	Victor Valdés V. Valdés	106	9,540	106	0	0.00			0
12	Cesc Fàbregas C. Fàbregas	104	8,283	94	20	0.19	5	25	5
13	José María Gutiérrez J. María Gutiérrez	97	6,040	63	16	0.16			0
14	Dani Carvajal D. Carvajal	96	7,655	86	2	0.02	17	19	0
15	Fernando Morientes F. Morientes	93	5,975	70	33	0.35			0
16	Álvaro Morata Á. Morata	89	5,056	57	29	0.33	8	37	0
17	Francisco Gento F. Gento	88	7,836	88	31	0.35			2
18	Iván Helguera I. Helguera	87	7,562	83	15	0.17			0
19	César Azpilicueta C. Azpilicueta	84	6,659	75	4	0.05	1	5	0
20	Jordi Alba J. Alba	84	6,684	79	3	0.04	13	16	0
21	Pedro	84	4,569	46	18	0.21	5	23	2
22	Lucas Vázquez L. Vázquez	82	4,276	43	4	0.05	12	16	0	0	51	12	4	3,774	9
23	Míchel Salgado M. Salgado	81	6,773	78	1	0.01			0
24	Thiago Alcântara T. Alcântara	80	5,769	62	9	0.11	10	19	0
25	Saúl	79	5,402	63	11	0.14	2	13	0	0	106	32	4	3,823	10