Between October 13, 2021 and October 13, 2026, Johan Vásquez has the most interceptions in Serie A, with 240 interceptions.
| NAME | INT | Rating | M | MIN | START | G | G/M | A | G+A | PK | FK | SH | SOT | WOOD | TCH | TCH-BOX | OFF | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | J. Vásquez | 240 | 6.65 | 167 | 13,626 | 153 | 8 | 0.05 | 1 | 9 | 0 | 0 | 124 | 30 | 8 | 9,813 | 220 | 8 |
| 2 |  | A. Buongiorno | 235 | 6.86 | 139 | 10,806 | 121 | 5 | 0.04 | 3 | 8 | 0 | 0 | 56 | 15 | 2 | 8,068 | 94 | 4 |
| 3 | | B. Gjimshiti | 210 | 6.84 | 153 | 11,530 | 133 | 2 | 0.01 | 5 | 7 | 0 | 0 | 67 | 10 | 2 | 8,752 | 135 | 0 |
| 4 |  | Bremer | 201 | 7.06 | 131 | 11,493 | 130 | 15 | 0.11 | 5 | 20 | 0 | 0 | 103 | 31 | 5 | 8,745 | 187 | 9 |
| 5 | | A. Grassi | 195 | 6.38 | 137 | 9,076 | 106 | 1 | 0.01 | 2 | 3 | 0 | 0 | 81 | 18 | 2 | 5,557 | 87 | 2 |
| 6 | | G. Mancini | 195 | 6.81 | 176 | 14,667 | 171 | 11 | 0.06 | 7 | 18 | 0 | 0 | 102 | 33 | 3 | 10,737 | 198 | 15 |
| 7 | | M. de Roon | 192 | 6.64 | 165 | 13,714 | 155 | 11 | 0.07 | 12 | 23 | 0 | 0 | 86 | 21 | 0 | 11,318 | 79 | 6 |
| 8 |  | G. Scalvini | 177 | 6.73 | 119 | 8,256 | 102 | 7 | 0.06 | 6 | 13 | 0 | 0 | 77 | 19 | 5 | 6,670 | 163 | 12 |
| 9 | | P. Marí | 168 | 6.69 | 122 | 9,980 | 113 | 3 | 0.02 | 0 | 3 | 0 | 0 | 37 | 10 | 1 | 7,532 | 62 | 1 |
| 10 | | M. Frendrup | 167 | 6.52 | 124 | 10,567 | 118 | 5 | 0.04 | 5 | 10 | 0 | 0 | 74 | 19 | 1 | 6,127 | 83 | 3 |
| 11 | | S. Luperto | 167 | 6.60 | 164 | 14,471 | 163 | 5 | 0.03 | 6 | 11 | 0 | 0 | 77 | 20 | 1 | 9,481 | 110 | 3 |
| 12 | | A. Ismajli | 163 | 6.68 | 124 | 9,686 | 105 | 0 | 0.00 | 1 | 1 | 0 | 0 | 28 | 7 | 0 | 6,311 | 62 | 1 |
| 13 | | A. Tameze | 162 | 6.51 | 141 | 9,252 | 105 | 4 | 0.03 | 4 | 8 | 0 | 0 | 54 | 13 | 0 | 5,801 | 103 | 2 |
| 14 |  | Éderson | 156 | 6.92 | 159 | 11,859 | 134 | 16 | 0.10 | 5 | 21 | 1 | 0 | 176 | 58 | 0 | 8,894 | 221 | 3 |
| 15 | | A. Marušić | 146 | 6.72 | 166 | 13,337 | 153 | 7 | 0.04 | 4 | 11 | 0 | 0 | 71 | 30 | 3 | 9,853 | 118 | 8 |
| 16 | | M. Badelj | 145 | 6.48 | 84 | 6,329 | 81 | 3 | 0.04 | 3 | 6 | 0 | 0 | 53 | 12 | 1 | 4,548 | 56 | 0 |
| 17 | | F. Acerbi | 143 | 7.06 | 124 | 9,819 | 108 | 7 | 0.06 | 5 | 12 | 0 | 0 | 56 | 17 | 4 | 8,476 | 109 | 13 |
| 18 |  | A. Zambo Anguissa | 143 | 6.99 | 147 | 11,672 | 133 | 13 | 0.09 | 13 | 26 | 0 | 0 | 168 | 46 | 6 | 9,281 | 326 | 10 |
| 19 | | A. Romagnoli | 137 | 6.90 | 141 | 11,716 | 133 | 5 | 0.04 | 0 | 5 | 0 | 0 | 63 | 26 | 5 | 9,502 | 109 | 7 |
| 20 | | Walace | 136 | 6.49 | 103 | 8,817 | 100 | 3 | 0.03 | 1 | 4 | 0 | 0 | 97 | 26 | 1 | 5,959 | 40 | 1 |
| 21 | | M. Locatelli | 135 | 7.00 | 166 | 13,188 | 154 | 5 | 0.03 | 13 | 18 | 1 | 0 | 136 | 37 | 2 | 12,077 | 108 | 5 |
| 22 | | F. Tomori | 135 | 6.90 | 138 | 11,175 | 130 | 5 | 0.04 | 4 | 9 | 0 | 0 | 46 | 17 | 0 | 9,332 | 74 | 4 |
| 23 | | N. Rovella | 132 | 6.96 | 111 | 7,331 | 85 | 1 | 0.01 | 9 | 10 | 0 | 0 | 67 | 17 | 1 | 6,812 | 39 | 6 |
| 24 | | R. Freuler | 129 | 6.95 | 122 | 9,973 | 116 | 4 | 0.03 | 8 | 12 | 0 | 0 | 58 | 15 | 0 | 8,010 | 116 | 2 |
| 25 | | J. Luis Palomino | 129 | 6.78 | 65 | 4,009 | 42 | 3 | 0.05 | 0 | 3 | 0 | 0 | 18 | 6 | 1 | 3,141 | 39 | 1 |
StatMuse has Serie A data for interceptions going back to the 2014-15 season.
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| 1 | 5 | 4 | 1 | 0 | 11 | 13 | |
| 2 | 5 | 4 | 1 | 0 | 7 | 13 | |
| 3 | 5 | 4 | 1 | 0 | 5 | 13 | |
| 4 | 5 | 4 | 0 | 1 | 3 | 12 | |
| 5 | 5 | 3 | 2 | 0 | 6 | 11 | |
| 6 | 5 | 3 | 1 | 1 | 5 | 10 | |
| 7 | 5 | 3 | 1 | 1 | 4 | 10 | |
| 8 | 5 | 3 | 1 | 1 | 3 | 10 | |
| 9 | 5 | 2 | 1 | 2 | 1 | 7 | |
| 10 | 5 | 2 | 1 | 2 | 0 | 7 | |
| 11 | 5 | 2 | 0 | 3 | -2 | 6 | |
| 12 | 5 | 2 | 0 | 3 | -5 | 6 | |
| 13 | 5 | 1 | 1 | 3 | -3 | 4 | |
| 14 | 5 | 1 | 1 | 3 | -3 | 4 | |
| 15 | 5 | 1 | 1 | 3 | -3 | 4 | |
| 16 | 5 | 1 | 1 | 3 | -4 | 4 | |
| 17 | 5 | 1 | 1 | 3 | -6 | 4 | |
| 18 | 5 | 0 | 2 | 3 | -3 | 2 | |
| 19 | 5 | 0 | 1 | 4 | -7 | 1 | |
| 20 | 5 | 0 | 0 | 5 | -9 | 0 |
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