Since 1999-00, Francesco Totti has the most goals in Serie A, with 214 goals.

most goals by a player scored from 2000 -2010

	NAME	G	M	MIN	START	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Francesco Totti F. Totti	214	472	36,699	424	0.45	46	260	67
2	Antonio Di Natale A. Di Natale	209	445	33,917	389	0.47	27	236	33
3	Ciro Immobile C. Immobile	201	354	26,952	310	0.57	49	250	52
4	Alberto Gilardino A. Gilardino	188	514	36,821	406	0.37	13	201	16
5	Fabio Quagliarella F. Quagliarella	182	556	38,059	432	0.33	34	216	32
6	Luca Toni L. Toni	157	344	27,181	307	0.46	16	173	17
7	Zlatan Ibrahimovic Z. Ibrahimovic	156	283	21,772	249	0.55	29	185	30
8	Alessandro Del Piero A. Del Piero	138	347	23,383	269	0.40	5	143	41
9	Paulo Dybala P. Dybala	129	352	23,948	278	0.37	66	195	33
10	Andriy Shevchenko A. Shevchenko	127	226	17,174	195	0.56			24
11	Marco Di Vaio M. Di Vaio	127	303	21,680	240	0.42	10	137	12
12	Gonzalo Higuaín G. Higuaín	125	224	17,108	193	0.56	29	154	12
13	Duván Zapata D. Zapata	124	327	22,028	253	0.38	43	167	7
14	Domenico Berardi D. Berardi	123	319	25,544	299	0.39	78	201	48
15	David Trezeguet D. Trezeguet	123	214	15,665	180	0.57			6
16	Mauro Icardi M. Icardi	121	219	17,197	193	0.55	27	148	19
17	Lautaro Martínez L. Martínez	117	242	16,846	193	0.48	27	144	11	0	763	295	20	7,386	1,296	95
18	Andrea Belotti A. Belotti	116	351	23,810	261	0.33	33	149	27	0	817	308	32	10,254	1,180	223
19	Giampaolo Pazzini G. Pazzini	115	383	22,728	231	0.30	8	123	24
20	Cristiano Lucarelli C. Lucarelli	115	276	21,603	247	0.42	0	115	23
21	Christian Vieri C. Vieri	114	193	13,002	135	0.59			15
22	Antonio Cassano A. Cassano	114	400	28,188	317	0.28	33	147	11
23	Dries Mertens D. Mertens	113	295	17,052	182	0.38	56	169	11
24	Hernán Crespo H. Crespo	113	258	17,140	193	0.44	0	113	12
25	Edinson Cavani E. Cavani	112	213	16,690	183	0.53	12	124	18