Between the 2001-02 and 2005-06 seasons, Ruud van Nistelrooy tallied the most goals by a Man United player in the Premier League, with 95 goals.

	NAME	G	M	MIN	START	G/M	A	G+A	PK
1	Ruud van Nistelrooy R. van Nistelrooy	95	150	12,181	137	0.63	14	109	18
2	Paul Scholes P. Scholes	42	149	11,913	132	0.28	16	58	0
3	Ryan Giggs R. Giggs	30	153	11,255	127	0.20	49	79	0
4	Wayne Rooney W. Rooney	27	65	5,260	58	0.42	11	38	0
5	Ole Gunnar Solskjær O. Gunnar Solskjær	26	83	5,373	59	0.31	17	43	0
6	Cristiano Ronaldo C. Ronaldo	18	95	6,257	64	0.19	14	32	0
7	David Beckham D. Beckham	17	59	4,643	50	0.29	16	33	1
8	Louis Saha L. Saha	15	45	2,680	28	0.33	5	20	0
9	Diego Forlán D. Forlán	10	63	2,486	23	0.16	6	16	0
10	Alan Smith A. Smith	7	52	3,508	37	0.13	6	13	0
11	Juan Sebastián Verón J. Sebastián Verón	7	51	3,804	45	0.14	4	11	0
12	Roy Keane R. Keane	7	113	9,318	104	0.06	11	18	0
13	John O'Shea J. O'Shea	5	131	9,779	112	0.04	3	8	0
14	Darren Fletcher D. Fletcher	4	67	4,752	58	0.06	5	9	0
15	Andy Cole A. Cole	4	11	710	7	0.36	3	7	0
16	Mikaël Silvestre M. Silvestre	4	171	14,167	161	0.02	15	19	0
17	David Bellion D. Bellion	3	24	659	5	0.13	1	4	0
18	Rio Ferdinand R. Ferdinand	3	116	10,287	115	0.03	4	7	0
19	Phil Neville P. Neville	3	103	7,280	81	0.03	3	6	0
20	Kléberson	2	20	1,208	16	0.10	4	6	0
21	Gary Neville G. Neville	2	137	11,356	126	0.01	13	15	0
22	Nicky Butt N. Butt	2	64	4,058	46	0.03	2	4	0
23	Giuseppe Rossi G. Rossi	1	5	129	1	0.20	0	1	0
24	Park Jisung P. Jisung	1	33	1,988	23	0.03	8	9	0
25	Gabriel Heinze G. Heinze	1	30	2,515	28	0.03	1	2	0