The Minnesota Twins had the lowest run differential by an AL team in 1999, with a differential of -159 runs.
| TEAM | DIFF | SEASON | G | W% | W | L | AB | R | H | 2B | 3B | HR | RBI | BB | HBP | SO | SB | CS | PA | TB | XBH | SH | SF | IBB | GIDP | AVG | OBP | SLG | OPS | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Twins | -159 | 1999 | 161 | .394 | 63 | 97 | 5,495 | 686 | 1,450 | 285 | 30 | 105 | 643 | 500 | 49 | 978 | 118 | 60 | 6,124 | 2,110 | 420 | 24 | 56 | 28 | 151 | .264 | .328 | .384 | .712 |
| 2 |  | Devil Rays | -141 | 1999 | 162 | .426 | 69 | 93 | 5,586 | 772 | 1,531 | 272 | 29 | 145 | 728 | 544 | 64 | 1,042 | 73 | 49 | 6,272 | 2,296 | 446 | 30 | 48 | 24 | 157 | .274 | .343 | .411 | .754 |
| 3 |  | Tigers | -135 | 1999 | 161 | .429 | 69 | 92 | 5,481 | 747 | 1,433 | 289 | 34 | 212 | 704 | 458 | 82 | 1,049 | 108 | 70 | 6,095 | 2,426 | 535 | 35 | 39 | 19 | 108 | .261 | .326 | .443 | .768 |
| 4 |  | Angels | -115 | 1999 | 162 | .432 | 70 | 92 | 5,494 | 711 | 1,404 | 248 | 22 | 158 | 673 | 511 | 43 | 1,022 | 71 | 45 | 6,131 | 2,170 | 428 | 41 | 42 | 24 | 135 | .256 | .322 | .395 | .716 |
| 5 |  | White Sox | -93 | 1999 | 162 | .466 | 75 | 86 | 5,644 | 777 | 1,563 | 298 | 37 | 162 | 742 | 499 | 34 | 810 | 110 | 50 | 6,262 | 2,421 | 497 | 40 | 45 | 22 | 138 | .277 | .337 | .429 | .766 |
| 6 |  | Royals | -65 | 1999 | 161 | .398 | 64 | 97 | 5,624 | 856 | 1,584 | 294 | 52 | 151 | 800 | 535 | 64 | 932 | 127 | 39 | 6,325 | 2,435 | 497 | 46 | 56 | 25 | 156 | .282 | .348 | .433 | .781 |
| 7 |  | Mariners | -46 | 1999 | 162 | .488 | 79 | 83 | 5,572 | 859 | 1,499 | 263 | 21 | 244 | 825 | 610 | 42 | 1,095 | 130 | 45 | 6,310 | 2,536 | 528 | 38 | 48 | 38 | 114 | .269 | .343 | .455 | .798 |
| 8 |  | Blue Jays | 21 | 1999 | 162 | .519 | 84 | 78 | 5,642 | 883 | 1,580 | 337 | 14 | 212 | 856 | 578 | 76 | 1,077 | 119 | 48 | 6,369 | 2,581 | 563 | 28 | 45 | 29 | 129 | .280 | .352 | .457 | .810 |
| 9 |  | Orioles | 36 | 1999 | 162 | .481 | 78 | 84 | 5,637 | 851 | 1,572 | 299 | 21 | 203 | 804 | 615 | 61 | 890 | 107 | 46 | 6,409 | 2,522 | 523 | 41 | 55 | 34 | 146 | .279 | .353 | .447 | .800 |
| 10 |  | Athletics | 47 | 1999 | 162 | .537 | 87 | 75 | 5,519 | 893 | 1,430 | 287 | 20 | 235 | 845 | 770 | 71 | 1,129 | 70 | 37 | 6,440 | 2,462 | 542 | 39 | 41 | 32 | 129 | .259 | .355 | .446 | .801 |
| 11 |  | Rangers | 86 | 1999 | 162 | .586 | 95 | 67 | 5,651 | 945 | 1,653 | 304 | 29 | 230 | 897 | 611 | 29 | 937 | 111 | 54 | 6,388 | 2,705 | 563 | 35 | 62 | 41 | 147 | .293 | .361 | .479 | .840 |
| 12 |  | Red Sox | 118 | 1999 | 162 | .580 | 94 | 68 | 5,579 | 836 | 1,551 | 334 | 42 | 176 | 808 | 597 | 55 | 928 | 67 | 39 | 6,321 | 2,497 | 552 | 34 | 56 | 27 | 131 | .278 | .350 | .448 | .798 |
| 13 |  | Indians | 149 | 1999 | 162 | .599 | 97 | 65 | 5,634 | 1,009 | 1,629 | 309 | 32 | 209 | 960 | 743 | 55 | 1,099 | 147 | 50 | 6,553 | 2,629 | 550 | 54 | 67 | 41 | 136 | .289 | .373 | .467 | .840 |
| 14 |  | Yankees | 169 | 1999 | 162 | .605 | 98 | 64 | 5,568 | 900 | 1,568 | 302 | 36 | 193 | 855 | 718 | 55 | 978 | 104 | 57 | 6,416 | 2,521 | 531 | 22 | 53 | 47 | 137 | .282 | .366 | .453 | .819 |
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