The Pittsburgh Pirates had the lowest run differential by a team in 2010, with a differential of -279 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Pirates	-279	2010	162	.352	57	105	5,386	587	1,303	276	27	126	570	463	33	1,207	87	36	5,973	2,011	429	58	33	28	119	.242	.304	.373	.678
2	Mariners	-185	2010	162	.377	61	101	5,409	513	1,274	227	16	101	485	459	39	1,184	142	39	5,989	1,836	344	42	40	33	110	.236	.298	.339	.637
3	Orioles	-172	2010	162	.407	66	96	5,554	613	1,440	264	21	133	577	424	54	1,056	76	34	6,108	2,145	418	31	45	32	154	.259	.316	.386	.702
4	Royals	-169	2010	162	.414	67	95	5,604	676	1,534	279	31	121	640	471	35	905	115	50	6,208	2,238	431	45	53	25	152	.274	.331	.399	.730
5	Diamondbacks	-123	2010	162	.401	65	97	5,473	713	1,366	301	34	180	691	589	39	1,529	86	41	6,183	2,275	515	41	41	45	113	.250	.325	.416	.740
6	Astros	-118	2010	162	.469	76	86	5,452	611	1,348	252	25	108	577	415	33	1,025	100	36	6,004	1,974	385	75	29	27	130	.247	.303	.362	.665
7	Indians	-106	2010	162	.426	69	93	5,487	646	1,362	290	20	128	601	545	64	1,184	91	33	6,165	2,076	438	36	33	34	118	.248	.322	.378	.700
8	Nationals	-87	2010	162	.426	69	93	5,418	655	1,355	250	31	149	634	503	60	1,220	110	41	6,099	2,114	430	71	47	36	125	.250	.318	.390	.708
9	Cubs	-82	2010	162	.463	75	87	5,512	685	1,414	298	27	149	658	479	50	1,236	55	31	6,139	2,213	474	60	38	32	124	.257	.320	.401	.721
10	Brewers	-54	2010	162	.475	77	85	5,606	750	1,471	293	33	182	710	546	81	1,216	81	26	6,303	2,376	508	35	35	35	115	.262	.335	.424	.759
11	Dodgers	-25	2010	162	.494	80	82	5,426	667	1,368	270	29	120	621	533	46	1,184	92	50	6,140	2,056	419	85	50	57	123	.252	.322	.379	.700
12	Angels	-21	2010	162	.494	80	82	5,488	681	1,363	276	19	155	656	466	52	1,070	104	52	6,085	2,142	450	42	37	28	125	.248	.311	.390	.702
13	Marlins	2	2010	162	.494	80	82	5,531	719	1,403	294	37	152	686	514	55	1,375	92	26	6,194	2,227	483	51	43	42	107	.254	.321	.403	.724
14	Mets	4	2010	162	.488	79	83	5,465	656	1,361	266	40	128	625	502	46	1,095	130	44	6,144	2,091	434	74	57	53	101	.249	.314	.383	.697
15	Tigers	8	2010	162	.500	81	81	5,643	751	1,515	308	32	152	717	546	41	1,147	69	30	6,312	2,343	492	41	41	50	118	.268	.335	.415	.750
16	Blue Jays	27	2010	162	.525	85	77	5,495	755	1,364	319	21	257	732	471	55	1,164	58	20	6,071	2,496	597	16	34	25	114	.248	.312	.454	.766
17	Athletics	37	2010	162	.500	81	81	5,448	663	1,396	276	30	109	619	527	47	1,061	156	38	6,116	2,059	415	43	51	16	129	.256	.324	.378	.702
18	White Sox	48	2010	162	.543	88	74	5,484	752	1,467	263	21	177	710	467	79	922	160	74	6,118	2,303	461	50	38	23	148	.268	.332	.420	.752
19	Rockies	53	2010	162	.512	83	79	5,530	770	1,452	270	54	173	741	585	47	1,274	99	41	6,265	2,349	497	56	47	53	103	.263	.336	.425	.760
20	Red Sox	74	2010	162	.549	89	73	5,646	818	1,511	358	22	211	782	587	47	1,140	68	17	6,355	2,546	591	29	46	43	130	.268	.339	.451	.790
21	Padres	84	2010	162	.556	90	72	5,434	665	1,338	236	24	132	630	538	50	1,183	124	50	6,147	2,018	392	79	46	67	106	.246	.317	.371	.689
22	Cardinals	95	2010	162	.531	86	76	5,542	736	1,456	285	18	150	689	541	50	1,027	79	41	6,239	2,227	453	66	40	78	124	.263	.332	.402	.733
23	Rangers	100	2010	162	.556	90	72	5,635	787	1,556	268	25	162	740	511	45	986	123	48	6,298	2,360	455	53	54	37	129	.276	.338	.419	.757
24	Reds	105	2010	162	.562	91	71	5,579	790	1,515	293	30	188	761	522	68	1,218	93	43	6,285	2,432	511	66	50	34	113	.272	.338	.436	.774
25	Braves	109	2010	162	.562	91	71	5,463	738	1,411	312	25	139	699	634	51	1,140	63	29	6,252	2,190	476	69	35	50	136	.258	.339	.401	.740