Between the 1995 and 2015 seasons, Roy Oswalt pitched the most innings for the Astros, with 1932.1 innings.

	NAME	IP	G	W	L	W%	GS	ERA	SO	CG	SHO	SV	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Roy Oswalt R. Oswalt	1932.1	303	143	82	.636	291	3.24	1,593	19	7	0	1,865	696	747	167	446	68	5	32	7,976	23	7.42	2.08	3.57	0.78	20.0	5.6	1.20	.298	3.48	76	3.35	77	8.69	217.7
2	Shane Reynolds S. Reynolds	1462.0	228	94	78	.547	228	4.00	1,179	19	6	0	1,557	649	713	159	325	27	0	22	6,177	34	7.26	2.00	3.63	0.98	19.1	5.3	1.29	.312	4.39	95	3.63	86	9.58	96.6
3	Wandy Rodriguez W. Rodriguez	1306.2	227	80	84	.488	218	4.04	1,093	2	2	0	1,295	587	664	147	454	45	1	31	5,577	34	7.53	3.13	2.41	1.01	19.6	8.1	1.34	.299	4.57	98	4.03	96	8.92	28.1
4	Mike Hampton M. Hampton	1096.2	172	74	49	.602	172	3.59	743	13	6	0	1,094	437	506	84	403	21	0	15	4,663	30	6.10	3.31	1.84	0.69	15.9	8.6	1.37	.296	4.15	89	3.92	95	8.98	23.1
5	Jose Lima J. Lima	804.0	167	46	42	.523	111	4.77	584	6	1	2	892	426	453	133	176	21	18	9	3,439	20	6.54	1.97	3.32	1.49	17.0	5.1	1.33	.301	5.07	109	4.55	104	9.99	-20.1
6	Wade Miller W. Miller	768.0	127	58	39	.598	123	3.87	659	5	1	0	699	330	362	91	306	23	2	14	3,246	18	7.72	3.59	2.15	1.07	20.3	9.4	1.31	.281	4.24	87	4.14	94	8.19	23.8
7	Bud Norris B. Norris	689.2	119	34	46	.425	118	4.33	643	0	0	0	687	332	368	85	281	26	0	13	3,001	22	8.39	3.67	2.29	1.11	21.4	9.4	1.40	.306	4.80	110	4.13	104	8.97	-10.9
8	Dallas Keuchel D. Keuchel	671.0	109	41	35	.539	100	3.58	523	9	3	0	649	267	291	62	190	15	2	6	2,778	25	7.01	2.55	2.75	0.83	18.8	6.8	1.25	.295	3.90	92	3.66	93	8.70	19.5
9	Darryl Kile D. Kile	601.2	94	35	30	.538	88	3.66	537	10	4	0	555	245	281	40	264	38	2	12	2,601	31	8.03	3.95	2.03	0.60	20.6	10.1	1.36	.299	4.20	92	3.71	92	8.30	20.4
10	Chris Holt C. Holt	585.1	103	21	42	.333	90	4.51	346	3	1	1	656	293	324	51	196	24	6	8	2,541	17	5.32	3.01	1.77	0.78	13.6	7.7	1.46	.314	4.98	103	4.19	97	10.09	9.5
11	Roger Clemens R. Clemens	539.0	84	38	18	.679	84	2.40	505	1	0	0	409	144	161	33	170	13	0	11	2,167	11	8.43	2.84	2.97	0.55	23.3	7.8	1.07	.260	2.69	56	2.99	68	6.83	84.4
12	Andy Pettitte A. Pettitte	519.2	84	37	26	.587	83	3.38	428	2	1	0	497	195	217	52	142	5	1	11	2,150	8	7.41	2.46	3.01	0.90	19.9	6.6	1.23	.292	3.76	78	3.57	80	8.61	49.3
13	Billy Wagner B. Wagner	504.1	464	26	29	.473	0	2.53	694	0	0	225	333	142	149	48	191	18	379	15	2,027	28	12.38	3.41	3.63	0.86	34.2	9.4	1.04	.265	2.66	59	2.80	66	5.94	83.4
14	Scott Elarton S. Elarton	483.1	120	32	21	.604	67	4.82	384	2	0	3	475	259	281	68	196	17	15	2	2,105	17	7.15	3.65	1.96	1.27	18.2	9.3	1.39	.283	5.23	106	4.67	103	8.84	-8.3
15	Brett Myers B. Myers	470.1	102	21	26	.447	66	3.77	360	4	0	19	473	197	221	55	129	9	30	9	1,987	10	6.89	2.47	2.79	1.05	18.1	6.5	1.28	.291	4.23	98	3.92	99	9.05	2.2
16	Brandon Backe B. Backe	467.2	108	30	28	.517	79	5.16	318	1	1	0	519	268	275	78	206	14	11	8	2,079	12	6.12	3.96	1.54	1.50	15.3	9.9	1.55	.301	5.29	122	5.30	121	9.99	-47.4
17	Octavio Dotel O. Dotel	449.0	302	22	24	.478	20	3.25	552	0	0	42	344	162	176	51	181	17	109	13	1,869	17	11.06	3.63	3.05	1.02	29.5	9.7	1.17	.274	3.53	71	3.38	75	6.90	53.9
18	Brian Moehler B. Moehler	434.2	125	21	28	.429	66	4.97	242	1	0	1	508	240	253	58	136	9	34	17	1,916	8	5.01	2.82	1.78	1.20	12.6	7.1	1.48	.306	5.24	119	4.74	110	10.52	-20.3
19	Tim Redding T. Redding	405.2	91	21	28	.429	72	4.75	290	0	0	0	444	214	245	52	167	15	4	10	1,808	12	6.43	3.71	1.74	1.15	16.0	9.2	1.51	.305	5.44	109	4.60	105	9.85	-9.8
20	Brad Lidge B. Lidge	401.0	378	23	20	.535	1	3.30	561	0	0	123	310	147	160	38	170	26	206	22	1,684	32	12.59	3.82	3.30	0.85	33.3	10.1	1.20	.306	3.59	76	2.98	67	6.96	64.4
21	Chad Qualls C. Qualls	384.2	380	27	22	.551	0	3.51	307	0	0	29	367	150	159	41	98	23	110	17	1,586	7	7.18	2.29	3.13	0.96	19.4	6.2	1.21	.292	3.72	84	3.85	89	8.59	19.5
22	Jordan Lyles J. Lyles	377.0	72	14	29	.326	65	5.35	259	1	1	1	431	224	256	51	117	21	3	6	1,685	7	6.18	2.79	2.21	1.22	15.4	6.9	1.45	.307	6.11	137	4.54	115	10.29	-24.2
23	Lucas Harrell L. Harrell	372.2	77	17	33	.340	59	4.81	248	1	1	0	390	199	223	35	182	8	8	11	1,660	20	5.99	4.40	1.36	0.85	14.9	11.0	1.53	.299	5.39	122	4.49	113	9.42	-21.7
24	Doug Drabek D. Drabek	360.1	61	17	18	.486	61	4.67	280	3	1	0	413	187	206	39	114	15	0	9	1,583	17	6.99	2.85	2.46	0.97	17.7	7.2	1.46	.330	5.15	118	4.06	100	10.32	-1.6
25	Chris Sampson C. Sampson	358.2	174	20	15	.571	33	4.42	176	0	0	3	390	176	190	40	87	12	26	14	1,517	6	4.42	2.18	2.02	1.00	11.6	5.7	1.33	.291	4.77	104	4.45	101	9.79	-1.9